Parkinson’s disease in 65 pairs of twins and in a set of quadruplets

Christopher D. Ward, Roger C. Duvoisin, Susan E. Ince, John D. Nutt, Roswell Eldridge, Donald B. Calne

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307 Citations (Scopus)

Abstract

Among 43 monozygotic (MZ) and 19 dizygotic (DZ) pairs in which an index case had definite Parkinson’s disease (PD), only one MZ pair was definitely concordant for PD. When pairs with questionable clinical features were included, 4 of 48 MZ and 1 of 19 DZ pairs were concordant. The frequency of PD in MZ cotwins of index cases with PD was similar to that expected in an unrelated control group matched for age and sex. Although we were unable to identify a single environmental agent, we conclude that the major factors in the etiology of PD are nongenetic.

Original languageEnglish (US)
Pages (from-to)815-824
Number of pages10
JournalNeurology
Volume33
Issue number7
StatePublished - 1983

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Parkinson Disease
Parkinson's Disease
Quadruplet
Control Groups

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Ward, C. D., Duvoisin, R. C., Ince, S. E., Nutt, J. D., Eldridge, R., & Calne, D. B. (1983). Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology, 33(7), 815-824.

Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. / Ward, Christopher D.; Duvoisin, Roger C.; Ince, Susan E.; Nutt, John D.; Eldridge, Roswell; Calne, Donald B.

In: Neurology, Vol. 33, No. 7, 1983, p. 815-824.

Research output: Contribution to journalArticle

Ward, CD, Duvoisin, RC, Ince, SE, Nutt, JD, Eldridge, R & Calne, DB 1983, 'Parkinson’s disease in 65 pairs of twins and in a set of quadruplets', Neurology, vol. 33, no. 7, pp. 815-824.
Ward CD, Duvoisin RC, Ince SE, Nutt JD, Eldridge R, Calne DB. Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology. 1983;33(7):815-824.
Ward, Christopher D. ; Duvoisin, Roger C. ; Ince, Susan E. ; Nutt, John D. ; Eldridge, Roswell ; Calne, Donald B. / Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. In: Neurology. 1983 ; Vol. 33, No. 7. pp. 815-824.
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