Parental preferences for CDKN2A/p16 testing of minors

Jennifer M. Taber, Lisa G. Aspinwall, Wendy Kohlmann, Reed Dow, Sancy A. Leachman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Purpose: Genetic testing of minors is controversial, as ethical considerations depend on multiple aspects of the particular disease and familial context. For melanoma, there is a well-established and avoidable environmental influence and a documented benefit of early detection. Methods: We surveyed 61 CDKN2A/p16 mutation-tested adults from two kindreds about their attitudes toward genetic testing of minors immediately posttesting and 2 years later. Results: Overall, 86.9% expressed support of melanoma genetic testing of minors, with the importance of risk awareness (77.4%) and the likelihood of improved prevention and screening behaviors (69.8%) as the most frequently cited potential benefits. Among mutation carriers, 82.6% wanted genetic testing for their own children. These preferences remained stable over a 2-year period. Most respondents (62.3%) favored complete involvement of their children in genetic counseling and test reporting; 19.7% suggested that children be tested but not informed of the results. Concerns about inducing psychological distress or compromising children's decision autonomy were infrequently cited. Testing preferences did not vary by respondent age, gender, or melanoma history. Conclusion: Respondents strongly supported melanoma genetic testing of minors, with most citing improved health behavior as a likely outcome. We discuss options for melanoma genetic counseling and testing of minors.

Original languageEnglish (US)
Pages (from-to)823-838
Number of pages16
JournalGenetics in Medicine
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • CDKN2A
  • children
  • familial melanoma
  • genetic counseling
  • prevention

ASJC Scopus subject areas

  • Genetics(clinical)

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