Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity

Hagai Tavori, Jacob Vaya, Michael Aviram

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Human atherosclerotic lesions contain a variety of lipids and oxidized lipids, which can induce atherogenic properties such as macrophage oxidation, lipoprotein oxidation and inhibition of cholesterol efflux from macrophages. These atherogenic properties of the plaque's lipid fraction are associated with the inhibition of paraoxonase 1 (PON1) lactonase activity. In contrast, incubation of PON1 with the plaque's lipid fraction reduces the lesion's atherogenic properties by lowering the capacity of the oxidized lipids to induce further oxidation. The mechanism of PON1's protective action and its endogenous substrate however remain elusive. Modeling studies may characterize PON1's possible active site, and help envisage the structure of potential endogenous and exogenous lactones as PON1 ligands. Such modeling thus may lead to a better understanding of PON1's anti-atherogenic mechanism of action.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages99-111
Number of pages13
Volume660
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume660
ISSN (Print)00652598

Fingerprint

Enzyme activity
Aryldialkylphosphatase
Lipids
Enzymes
Macrophages
Oxidation
Lactones
Lipoproteins
Catalytic Domain
Cholesterol
human PON1 protein
Ligands
Substrates

Keywords

  • Atherosclerosis
  • Docking
  • Lactones
  • Modeling
  • Oxidative stress
  • Paraoxonase
  • Plaque

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tavori, H., Vaya, J., & Aviram, M. (2010). Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity. In Advances in Experimental Medicine and Biology (Vol. 660, pp. 99-111). (Advances in Experimental Medicine and Biology; Vol. 660). https://doi.org/10.1007/978-1-60761-350-3_10

Paraoxonase 1 attenuates human plaque atherogenicity : Relevance to the enzyme lactonase activity. / Tavori, Hagai; Vaya, Jacob; Aviram, Michael.

Advances in Experimental Medicine and Biology. Vol. 660 2010. p. 99-111 (Advances in Experimental Medicine and Biology; Vol. 660).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tavori, H, Vaya, J & Aviram, M 2010, Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity. in Advances in Experimental Medicine and Biology. vol. 660, Advances in Experimental Medicine and Biology, vol. 660, pp. 99-111. https://doi.org/10.1007/978-1-60761-350-3_10
Tavori H, Vaya J, Aviram M. Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity. In Advances in Experimental Medicine and Biology. Vol. 660. 2010. p. 99-111. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-60761-350-3_10
Tavori, Hagai ; Vaya, Jacob ; Aviram, Michael. / Paraoxonase 1 attenuates human plaque atherogenicity : Relevance to the enzyme lactonase activity. Advances in Experimental Medicine and Biology. Vol. 660 2010. pp. 99-111 (Advances in Experimental Medicine and Biology).
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