Paraneoplastic retinopathy associated with systemic follicular cell lymphoma

Kavita Bhavsar, Thomas Hedges, Charles E. Thirkill, Elias Reichel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The authors describe two rare cases of autoimmune retinopathy associated with follicular cell lymphoma, including a 54-year-old man who experienced nyctalopia for 1 year (patient 1) and a 59-year-old man who had bilateral loss of central vision for 6 months (patient 2). Visual field testing of patient 1 revealed nonspecific defects, and multifocal electroretinogram (ERG) testing showed mildly subnormal amplitudes more pronounced in the left than the right eye. Serologic testing detected antibodies against a 47-kD protein, presumed to be alpha-enolase. Goldmann perimetry of patient 2 showed dense central scotomas, and a full-field ERG revealed reduced amplitudes of bright scotopic responses. Serological testing yielded antibipolar cell antibodies. A variable presentation of autoimmune retinopathy can occur in the setting of follicular cell lymphoma. Disparate serum autoantibodies may have mediated the pathogenesis of retinal degeneration in these two patients and could explain the difference in course and severity of retinopathy.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Follicular Lymphoma
Night Blindness
Scotoma
Retinal Degeneration
Visual Field Tests
Phosphopyruvate Hydratase
Antibodies
Visual Fields
Autoantibodies
Serum
Proteins

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery
  • Medicine(all)

Cite this

Paraneoplastic retinopathy associated with systemic follicular cell lymphoma. / Bhavsar, Kavita; Hedges, Thomas; Thirkill, Charles E.; Reichel, Elias.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 3, 01.03.2015, p. 373-376.

Research output: Contribution to journalArticle

Bhavsar, Kavita ; Hedges, Thomas ; Thirkill, Charles E. ; Reichel, Elias. / Paraneoplastic retinopathy associated with systemic follicular cell lymphoma. In: Ophthalmic Surgery Lasers and Imaging Retina. 2015 ; Vol. 46, No. 3. pp. 373-376.
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