Parallel assisted assembly of multilayer DNA and protein nanoparticle structures using a CMOS electronic array

Michael J. Heller, Dietrich A. Dehlinger, Benjamin D. Sullivan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A CMOS electronic microarray device was used to carry out the rapid parallel assembly of functionalized nanoparticles into multilayer structures. Electronic microarrays produce reconfigurable DC electric fields that allow DNA, proteins as well as charged molecules to be rapidly transported from the bulk solution and addressed to specifically activated sites on the array surface. Such a device was used to carry out the assisted self-assembly DNA, biotin and streptavidin derivatized fluorescent nanoparticles into multilayer structures. Nanoparticle addressing could be carried out in about 15 seconds, and forty depositions of nanoparticles were completed in less than one hour. The final multilayered 3D nanostructures were verified by scanning electron microscopy.

Original languageEnglish (US)
Title of host publicationDNA-BASED NANOSCALE INTEGRATION
Subtitle of host publicationInternational Symposium on DNA-Based Nanoscale Integration
PublisherAmerican Institute of Physics Inc.
Pages73-81
Number of pages9
ISBN (Print)0735403570, 9780735403574
DOIs
StatePublished - 2006
EventDNA-BASED NANOSCALE INTEGRATION: International Symposium on DNA-Based Nanoscale Integration - Jena, Germany
Duration: May 18 2006May 20 2006

Publication series

NameAIP Conference Proceedings
Volume859
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceDNA-BASED NANOSCALE INTEGRATION: International Symposium on DNA-Based Nanoscale Integration
CountryGermany
CityJena
Period5/18/065/20/06

Keywords

  • CMOS
  • DNA
  • Electric field
  • Microarrays
  • Nanoparticles
  • Proteins
  • Self-assembly

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Heller, M. J., Dehlinger, D. A., & Sullivan, B. D. (2006). Parallel assisted assembly of multilayer DNA and protein nanoparticle structures using a CMOS electronic array. In DNA-BASED NANOSCALE INTEGRATION: International Symposium on DNA-Based Nanoscale Integration (pp. 73-81). (AIP Conference Proceedings; Vol. 859). American Institute of Physics Inc.. https://doi.org/10.1063/1.2360589