TY - JOUR
T1 - p202 self-associates through a sequence conserved among the members of the 200-family proteins
AU - Koul, Dimpy
AU - Obeyesekere, Nihal U.
AU - Gutterman, Jordan U.
AU - Mills, Gordon B.
AU - Choubey, Divaker
N1 - Funding Information:
This research was supported by a grant (CA69031) from the National Institutes of Health to D.C.
PY - 1998/10/30
Y1 - 1998/10/30
N2 - Murine p202 is an interferon-inducible primarily nuclear phosphoprotein (52 kDa) whose expression in transfected cells inhibits colony formation. p202-binding proteins include the pocket proteins (pRb, p107 and p130), a p53-binding protein (sm53BP1), and transcription factors (e.g. NF-κB (p50 and p65), AP-1 (c-Fos and c-Jun), E2F-1, E2F-4, MyoD, and myogenin). p202 modulates the transcriptional activity of these factors in transfected cells. Here we demonstrate that p202 self-associates directly and a sequence in p202, which is conserved among the members of the 200-family proteins, was sufficient for self-association in vitro. Our observations reported herein raise the possibility that self-association of p202 may provide a mechanism for the regulation of its activity. Copyright (C) 1998 Federation of European Biochemical Societies.
AB - Murine p202 is an interferon-inducible primarily nuclear phosphoprotein (52 kDa) whose expression in transfected cells inhibits colony formation. p202-binding proteins include the pocket proteins (pRb, p107 and p130), a p53-binding protein (sm53BP1), and transcription factors (e.g. NF-κB (p50 and p65), AP-1 (c-Fos and c-Jun), E2F-1, E2F-4, MyoD, and myogenin). p202 modulates the transcriptional activity of these factors in transfected cells. Here we demonstrate that p202 self-associates directly and a sequence in p202, which is conserved among the members of the 200-family proteins, was sufficient for self-association in vitro. Our observations reported herein raise the possibility that self-association of p202 may provide a mechanism for the regulation of its activity. Copyright (C) 1998 Federation of European Biochemical Societies.
KW - 200-family proteins
KW - Conserved sequence
KW - Protein-protein interaction motif
KW - Self-association
KW - p202
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U2 - 10.1016/S0014-5793(98)01263-0
DO - 10.1016/S0014-5793(98)01263-0
M3 - Article
C2 - 9821952
AN - SCOPUS:0032582703
SN - 0014-5793
VL - 438
SP - 21
EP - 24
JO - FEBS Letters
JF - FEBS Letters
IS - 1-2
ER -