P-052. Effect of growth hormone on insulin-like growth factors and their binding proteins in children on long-term steroids

X. Zhou, K. Y. Loke, H. K. Yap, B. W. Lee, Ronald (Ron) Rosenfeld, K. O. Lee

Research output: Contribution to journalArticle

Abstract

Changes in the insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) with growth hormone (GH) treatment in children on chronic steroids are not well characterized. Six children (9.8-16.8 yr) with long standing steroid dependent nephrotic syndrome had serum samples analyzed before and during one year GH treatment, nineteen healthy age-matched children (5.9-12.0 yr) acted as controls. Before treatment, all six children had severe short stature, low height velocity and suppressed GH levels. However, surprisingly, serum levels of total IGF-I, total IGF-II and 'free' IGF-I (RIA, Diagnostic Systems Laboratories, TX) were elevated significantly compared to the control group (p

Original languageEnglish (US)
Pages (from-to)55
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Volume4
Issue numberA
Publication statusPublished - 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology

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