Changes in the insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) with growth hormone (GH) treatment in children on chronic steroids are not well characterized. Six children (9.8-16.8 yr) with long standing steroid dependent nephrotic syndrome had serum samples analyzed before and during one year GH treatment, nineteen healthy age-matched children (5.9-12.0 yr) acted as controls. Before treatment, all six children had severe short stature, low height velocity and suppressed GH levels. However, surprisingly, serum levels of total IGF-I, total IGF-II and 'free' IGF-I (RIA, Diagnostic Systems Laboratories, TX) were elevated significantly compared to the control group (p<0.05). In contrast, serum IGFBP-1, -2, -3, and -4 measured by densitometry after Western Ligand Blot (WLB), and serum MFBP-3 level measured by RIA, did not differ significantly from controls (p = 0.54). During GH treatment, serum total IGF-I, 'free' IGF-I levels and serum IGFBP-3 increased further and significantly (p<0.05), but levels of other IGFBPs did not change significantly. In conclusion, children on long-term steroids have higher serum total IGF-I, IGF-II, and 'free' MF-I, compared to healthy age-matched controls. Serum total IGF-I, 'free' IGF-I and IGFBP-3 increase further with GH treatment.
|Original language||English (US)|
|Number of pages||1|
|Journal||Endocrinology and Metabolism, Supplement|
|State||Published - 1997|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism