Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin

D. M. Gibbs; W. Vale; J. Rivier; S. S.C. Yen

doi:10.1016/0024-3205(84)90212-1

Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin

D. M. Gibbs, W. Vale, J. Rivier, S. S.C. Yen

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10^-9M) and AVP (10^-8M) alone produced a significant increase in ACTH secretion while OT (10^-8M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.

Original language	English (US)
Pages (from-to)	2245-2249
Number of pages	5
Journal	Life Sciences
Volume	34
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(84)90212-1
State	Published - Jun 4 1984
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(84)90212-1

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title = "Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin",

abstract = "The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10-9M) and AVP (10-8M) alone produced a significant increase in ACTH secretion while OT (10-8M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.",

author = "Gibbs, {D. M.} and W. Vale and J. Rivier and Yen, {S. S.C.}",

note = "Funding Information: This work was supported in part by a Mellon Foundation Faculty Scholar Award and by NIH grants AM-32517, HD-12303, and HD-13527. The research was conducted in part by the Clayton Foundation for Research, California Division.",

year = "1984",

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doi = "10.1016/0024-3205(84)90212-1",

language = "English (US)",

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T1 - Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin

AU - Gibbs, D. M.

AU - Vale, W.

AU - Rivier, J.

AU - Yen, S. S.C.

N1 - Funding Information: This work was supported in part by a Mellon Foundation Faculty Scholar Award and by NIH grants AM-32517, HD-12303, and HD-13527. The research was conducted in part by the Clayton Foundation for Research, California Division.

PY - 1984/6/4

Y1 - 1984/6/4

N2 - The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10-9M) and AVP (10-8M) alone produced a significant increase in ACTH secretion while OT (10-8M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.

AB - The effects of CRF(41), oxytocin (OT), and arginine vasopressin (AVP) on ACTH secretion were studied alone and in combination in an in vitro system of superfused rat hemipituitaries. CRF(41) (10-9M) and AVP (10-8M) alone produced a significant increase in ACTH secretion while OT (10-8M) alone had no effect. However the same concentration of OT markedly potentiated the ACTH response to CRF(41) while having no effect on the ACTH response to AVP. The data support a physiologic role for OT in the regulation of ACTH secretion.

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JO - Life Sciences

JF - Life Sciences

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ER -

Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin

Abstract

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