Oxygen transport in the myocardium

J. B. Bassingthwaighte, A. Deussen, D. Beyer, I. S. Chan, G. R. Raymond, R. B. King, T. R. Bukowski, J. D. Ploger, K. Kroll, J. Revenaugh, A. Deussen, J. M. Link, K. A. Krohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

15O-oxygen is metabolized carbon dioxide and converts to 15O-water in myocardial mitochondria. To determine the rate of this reaction from the analysis of time activity curves obtained via positron emission tomography or from outflow dilution curves, we apply a mathematical model accounting for convective and transmembrane transport, for transformation in tissue and for measures of the anatomic structures. The model describes gradients in concentrations along capillary tissue units, permeation of endothelial and parenchymal cell barriers (using appropriate binding spaces to account for O2 binding to hemoglobin and myoglobin), production of 15O-water in parenchymal cells, and the permeation and transport of 15O-water into effluent blood. The modeling analysis gives estimates of rates of oxygen consumption which are within a few percent of estimates obtained by the standard Fick technique which uses the product of flow times the arteriovenous differences in oxygen concentrations.

Original languageEnglish (US)
Title of host publicationAdvaces in Biological Heat and Mass Transfer - 1992
PublisherPubl by ASME
Pages113-119
Number of pages7
ISBN (Print)0791811115
StatePublished - 1992
Externally publishedYes
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Anaheim, CA, USA
Duration: Nov 8 1992Nov 13 1992

Publication series

NameAmerican Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
Volume231
ISSN (Print)0272-5673

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAnaheim, CA, USA
Period11/8/9211/13/92

ASJC Scopus subject areas

  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

Fingerprint Dive into the research topics of 'Oxygen transport in the myocardium'. Together they form a unique fingerprint.

Cite this