Oxidative DNA damage in disease-Insights gained from base excision repair glycosylase-deficient mouse models

Harini Sampath

Research output: Contribution to journalReview article

22 Scopus citations


Cellular components, including nucleic acids, are subject to oxidative damage. If left unrepaired, this damage can lead to multiple adverse cellular outcomes, including increased mutagenesis and cell death. The major pathway for repair of oxidative base lesions is the base excision repair pathway, catalyzed by DNA glycosylases with overlapping but distinct substrate specificities. To understand the role of these glycosylases in the initiation and progression of disease, several transgenic mouse models have been generated to carry a targeted deletion or overexpression of one or more glycosylases. This review summarizes some of the major findings from transgenic animal models of altered DNA glycosylase expression, especially as they relate to pathologies ranging from metabolic disease and cancer to inflammation and neuronal health.

Original languageEnglish (US)
Pages (from-to)689-703
Number of pages15
JournalEnvironmental and Molecular Mutagenesis
Issue number9
StatePublished - Dec 1 2014



  • Base-excision repair
  • MUTY
  • Mouse models
  • NEIL1
  • NTH1
  • OGG1
  • Oxidative stress

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

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