Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation

Shi Long Lu, Douglas Reh, Allen G. Li, Jennifer Woods, Christopher Corless, Molly Kulesz-Martin, Xiao Jing Wang

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

In the present study, we show that transforming growth factor β1 (TGF-β1) was frequently overexpressed in human head and neck squamous cell carcinomas (HNSCCs) and adjacent tissues in comparison with normal head and neck tissues. To determine the role of TGF-β1 overexpression in HNSCC carcinogenesis, we generated transgenic mice in which TGF-β1 transgene expression can be induced in head and neck epithelia. TGF-β1 transgene induction in head and neck epithelia, at levels similar to those in human HNSCCs, caused severe inflammation and angiogenesis. Consequently, TGF-β1-transgenic epithelia exhibited hyperproliferation. These phenotypes correlated with enhanced Smad signaling in transgenic epithelia and stroma. Our study suggests that TGF-β1 overexpression at early stages of HNSCC formation provides a tumor promoting microenvironment.

Original languageEnglish (US)
Pages (from-to)4405-4410
Number of pages6
JournalCancer Research
Volume64
Issue number13
DOIs
StatePublished - Jul 1 2004

Fingerprint

Transforming Growth Factors
Neck
Epithelium
Head
Inflammation
Transgenes
Tumor Microenvironment
Transgenic Mice
Carcinogenesis
Phenotype
Carcinoma, squamous cell of head and neck

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. / Lu, Shi Long; Reh, Douglas; Li, Allen G.; Woods, Jennifer; Corless, Christopher; Kulesz-Martin, Molly; Wang, Xiao Jing.

In: Cancer Research, Vol. 64, No. 13, 01.07.2004, p. 4405-4410.

Research output: Contribution to journalArticle

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