Ovarian steroid action in the serotonin neural system of macaques

Cynthia Bethea, Chrisana Gundlah, Stephanie J. Mirkes

Research output: Chapter in Book/Report/Conference proceedingChapter

56 Citations (Scopus)

Abstract

The serotonin neural system plays an important role in cognitive, emotional and endocrine processes. If the ovarian hormones, oestrogen and progesterone, alter serotonin neural transmission, then functional changes in all of these systems would follow. Therefore, information on the effects of oestrogen and progesterone at a molecular level in the serotonin neural system was sought using non-human primates. Serotonin neurons express nuclear oestrogen receptor β (ERβ) and progesterone receptors (PRs) which are gene transcription factors. Within serotonin neurons, the regulation of three genes related to serotonin neurotransmission was examined. The mRNA for tryptophan hydroxylase (TPH), the committal enzyme in serotonin synthesis, increased significantly with oestrogen treatment and remained elevated when progesterone was added to the oestrogen regimen. Serotonin reuptake transporter (SERT) mRNA decreased significantly with oestrogen treatment and addition of progesterone had no further effect. 5-HT1A autoreceptor mRNA decreased significantly with oestrogen treatment and addition of progesterone caused a further decrease. Little or no regulation of postsynaptic 5-HT1A, 5-HT2A or 5-HT2C receptor mRNAs was observed in hypothalamic target neurons. TPH protein is increased by oestrogen treatment and remains elevated with addition of progesterone in a manner similar to TPH mRNA. Medroxyprogesterone (MPA) blocked the stimulatory effect of oestrogen on TPH protein and tamoxifen reduced TPH protein levels below that observed in spayed monkeys. Together these data indicate that ovarian hormones and their synthetic analogues could modify cognitive and autonomic neural functions by acting on the serotonin neural pathway.

Original languageEnglish (US)
Title of host publicationNovartis Foundation Symposium
Pages112-133
Number of pages22
Volume230
StatePublished - 2000
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
Volume230

Fingerprint

Macaca
Tryptophan Hydroxylase
Serotonin
Estrogens
Steroids
Progesterone
Messenger RNA
Neurons
Synaptic Transmission
Medroxyprogesterone
Hormones
Receptor, Serotonin, 5-HT2C
Neural Pathways
Autoreceptors
Serotonin Plasma Membrane Transport Proteins
Proteins
Progesterone Receptors
Tamoxifen
Estrogen Receptors
Primates

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bethea, C., Gundlah, C., & Mirkes, S. J. (2000). Ovarian steroid action in the serotonin neural system of macaques. In Novartis Foundation Symposium (Vol. 230, pp. 112-133). (Novartis Foundation Symposium; Vol. 230).

Ovarian steroid action in the serotonin neural system of macaques. / Bethea, Cynthia; Gundlah, Chrisana; Mirkes, Stephanie J.

Novartis Foundation Symposium. Vol. 230 2000. p. 112-133 (Novartis Foundation Symposium; Vol. 230).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bethea, C, Gundlah, C & Mirkes, SJ 2000, Ovarian steroid action in the serotonin neural system of macaques. in Novartis Foundation Symposium. vol. 230, Novartis Foundation Symposium, vol. 230, pp. 112-133.
Bethea C, Gundlah C, Mirkes SJ. Ovarian steroid action in the serotonin neural system of macaques. In Novartis Foundation Symposium. Vol. 230. 2000. p. 112-133. (Novartis Foundation Symposium).
Bethea, Cynthia ; Gundlah, Chrisana ; Mirkes, Stephanie J. / Ovarian steroid action in the serotonin neural system of macaques. Novartis Foundation Symposium. Vol. 230 2000. pp. 112-133 (Novartis Foundation Symposium).
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