Ovarian reserve tests and their utility in predicting response to controlled ovarian stimulation in rhesus monkeys

Julie M. Wu, Diana L. Takahashi, Donald K. Ingram, Julie A. Mattison, George Roth, Mary Ann Ottinger, Mary B. Zelinski

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    Controlled ovarian stimulation (COS) is an alternative to natural breeding in nonhuman primates; however, these protocols are costly with no guarantee of success. Toward the objective of predicting COS outcome in rhesus monkeys, this study evaluated three clinically used ovarian reserve tests (ORTs): day 3 (d3) follicle-stimulating hormone (FSH) with d3 inhibin B (INHB), the clomiphene citrate challenge test (CCCT), and the exogenous FSH Ovarian Reserve Test. A COS was also performed and response was classified as either successful (COS+) or unsuccessful (COS-) and retrospectively compared with ORT predictions. FSH and INHB were assessed for best hormonal index in conjunction with the aforementioned tests. INHB was consistently more accurate than FSH in all the ORTs used. Overall, a modified version of the CCCT using INHB values yielded the best percentage of correct predictions. This is the first report of ORT evaluation in rhesus monkeys and may provide a useful diagnostic test before costly follicle stimulations, as well as predicting the onset of menopause.

    Original languageEnglish (US)
    Pages (from-to)672-680
    Number of pages9
    JournalAmerican Journal of Primatology
    Volume72
    Issue number8
    DOIs
    StatePublished - Aug 1 2010

    Keywords

    • Follicular response
    • Hormone predictors of fertility
    • Inhibin
    • Ovarian reserve
    • Peri-menopause

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Animal Science and Zoology

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