Ovarian cancer: Homeobox genes, autocrine/paracrine growth, and kinase signaling

B. T. Hennessy, G. B. Mills

Research output: Contribution to journalShort surveypeer-review

18 Scopus citations

Abstract

Epithelial ovarian cancer, the fourth leading cause of cancer deaths in American women, is currently classified by surgical and histologic appearance. However, the predictive value of this classification is limited. The risk of epithelial ovarian cancer increases with the number of ovulatory events. It is now thought that different ovarian tumors are derived from a single ovarian surface epithelial precursor cell with the degree and pattern of differentiation determined by combinatorial expression of homeobox genes normally involved in differentiation of the female genital tract. This aberrant differentiation occurs in association with histology-specific genomic aberrations, genomic instability, and resultant chromosomal changes, and may be triggered by prolonged abnormal or excessive exposure of surface epithelial cells to autocrine/paracrine stimulation by sex steroids and other growth factors. As the disease progresses, activation of kinase pathways and continued abnormal autocrine/paracrine stimulation contribute to genomic instability but also identify potential targets for novel therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1450-1456
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number9
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Cancer
  • Genomic
  • Molecular
  • Ovarian

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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