Ovarian cancer: Homeobox genes, autocrine/paracrine growth, and kinase signaling

B. T. Hennessy, Gordon Mills

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

Epithelial ovarian cancer, the fourth leading cause of cancer deaths in American women, is currently classified by surgical and histologic appearance. However, the predictive value of this classification is limited. The risk of epithelial ovarian cancer increases with the number of ovulatory events. It is now thought that different ovarian tumors are derived from a single ovarian surface epithelial precursor cell with the degree and pattern of differentiation determined by combinatorial expression of homeobox genes normally involved in differentiation of the female genital tract. This aberrant differentiation occurs in association with histology-specific genomic aberrations, genomic instability, and resultant chromosomal changes, and may be triggered by prolonged abnormal or excessive exposure of surface epithelial cells to autocrine/paracrine stimulation by sex steroids and other growth factors. As the disease progresses, activation of kinase pathways and continued abnormal autocrine/paracrine stimulation contribute to genomic instability but also identify potential targets for novel therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1450-1456
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number9
DOIs
StatePublished - May 22 2006
Externally publishedYes

Fingerprint

Homeobox Genes
Genomic Instability
Neoplasm Genes
Ovarian Neoplasms
Phosphotransferases
Genes
Epithelial Cells
Histology
Growth
Aberrations
Tumors
Cause of Death
Neoplasms
Intercellular Signaling Peptides and Proteins
Chemical activation
Steroids
Association reactions
Ovarian epithelial cancer
Therapeutics

Keywords

  • Cancer
  • Genomic
  • Molecular
  • Ovarian

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Ovarian cancer : Homeobox genes, autocrine/paracrine growth, and kinase signaling. / Hennessy, B. T.; Mills, Gordon.

In: International Journal of Biochemistry and Cell Biology, Vol. 38, No. 9, 22.05.2006, p. 1450-1456.

Research output: Contribution to journalShort survey

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