Ovarian aging and menopause

Current theories, hypotheses, and research models

Julie M. Wu, Mary Zelinski, Donald K. Ingram, Mary Ann Ottinger

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    Aging of the reproductive system has been studied in numerous vertebrate species. Although there are wide variations in reproductive strategies and hormone cycle components, many of the fundamental changes that occur during aging are similar. Evolutionary hypotheses attempt to explain why menopause occurs, whereas cellular hypotheses attempt to explain how it occurs. It is commonly believed that a disruption in the hypothalamic-pituitary-gonadal axis is responsible for the onset of menopause. Data exist to demonstrate that the first signs of menopause occur at the level of the brain or the ovary. Thus, finding an appropriate and representative animal model is especially important for the advancement of menopause research. In primates, there is a gradual decline in the function of the hypothalamic-pituitary-gonadal (HPG) axis ultimately resulting in irregularities in menstrual cycles and increasingly sporadic incidence of ovulation. Rodents also exhibit a progressive deterioration in HPG axis function; however, they also experience a period of constant estrus accompanied by intermittent ovulations, reduced progesterone levels, and elevated circulating estradiol levels. It is remarkable to observe that females of other classes also demonstrate deterioration in HPG axis function and ovarian failure. Comparisons of aging in various taxa provide insight into fundamental biological mechanisms of aging that could underlie reproductive decline.

    Original languageEnglish (US)
    Pages (from-to)818-828
    Number of pages11
    JournalExperimental Biology and Medicine
    Volume230
    Issue number11
    StatePublished - Dec 2005

    Fingerprint

    Menopause
    Aging of materials
    Ovulation
    Research
    Deterioration
    Estrus
    Menstrual Cycle
    Primates
    Progesterone
    Vertebrates
    Ovary
    Estradiol
    Rodentia
    Brain
    Animals
    Animal Models
    Hormones
    Incidence

    Keywords

    • Animal models
    • Inhibin
    • Ovarian aging
    • Ovarian steroid hormones
    • Ovulatory cycles
    • Perimenopause

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Ovarian aging and menopause : Current theories, hypotheses, and research models. / Wu, Julie M.; Zelinski, Mary; Ingram, Donald K.; Ottinger, Mary Ann.

    In: Experimental Biology and Medicine, Vol. 230, No. 11, 12.2005, p. 818-828.

    Research output: Contribution to journalArticle

    Wu, Julie M. ; Zelinski, Mary ; Ingram, Donald K. ; Ottinger, Mary Ann. / Ovarian aging and menopause : Current theories, hypotheses, and research models. In: Experimental Biology and Medicine. 2005 ; Vol. 230, No. 11. pp. 818-828.
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