Outer hair cell electromotility in vivo

Sripriya Ramamoorthy, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effectiveness of outer hair cell (OHC) electro-motility in vivo has been challenged by the expected low-pass filtering of the transmembrane potential due to the cell's own capacitance. The OHC electromotility is characterized here by an electromechanical ratio defined as the ratio of the OHC contraction to the transmembrane potential. This ratio has been measured in isolated cells to be approximately 26 nm/mV. We estimate the OHC electromechanical ratio in vivo from the recently measured displacements of the reticular lamina and the basilar membrane near the 19 kHz characteristic frequency in the basal region of guinea pig cochlea. Our analysis strongly suggests OHC electromotility process is effective for cochlear amplification in vivo at least around the characteristic frequency of the basal location in spite of the low-pass filtering.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages176-178
Number of pages3
DOIs
StatePublished - Dec 12 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

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Keywords

  • active force
  • amplification
  • hair bundle motility
  • micromechanics
  • outer hair cell electromotility

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Ramamoorthy, S., & Nuttall, A. L. (2011). Outer hair cell electromotility in vivo. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (pp. 176-178). (AIP Conference Proceedings; Vol. 1403). https://doi.org/10.1063/1.3658082