Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS)

Erick D. Bothun, M. Edward Wilson, Elias I. Traboulsi, Nancy N. Diehl, David A. Plager, Deborah K. Vanderveen, Sharon F. Freedman, Kimberly G. Yen, Natalie C. Weil, Allison Loh, David Morrison, Jill S. Anderson, Scott R. Lambert, Scott Lambert, Amy Hutchinson, Stephen Christiansen, Erick Bothun, Ed Wilson, Elias Traboulsi, David PlagerDaniel Neely, Deborah Vanderveen, Ed Buckley, Sharon Freedman, David Wallace, Kimberly Yen, David Wheeler

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Purpose: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. Design: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Participants: The Toddler Aphakia and Pseudophakia Study is a registry of children treated by surgeons who participated in the IATS. Methods: Children underwent unilateral cataract surgery with or without intraocular lens (IOL) placement during the IATS enrollment years of 2004 and 2010. Main Outcome Measures: Intraoperative complications, adverse events (AEs), visual acuity, and strabismus. Results: Fifty-six children were included with a mean postoperative follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 7.2–22.9). Ninety-two percent received a primary IOL. Intraoperative complications occurred in 4 patients (7%). At 5 years of age, visual acuity of treated eyes was very good (≥20/40) in 11% and poor (≤20/200) in 44%. Adverse events were identified in 24%, with a 4% incidence of glaucoma suspect. An additional unplanned intraocular surgery occurred in 14% of children. Neither AEs nor intraocular reoperations were more common for children with surgery at 7 to 12 months of age than for those who underwent surgery at 13 to 24 months of age (AE rate, 21% vs. 25% [P = 0.60]; reoperation rate, 13% vs. 16% [P = 1.00]). Conclusions: Although most children underwent IOL implantation concurrent with unilateral cataract removal, the incidence of complications, reoperations, and glaucoma was low when surgery was performed between 7 and 24 months of age and compared favorably with same-site IATS data for infants undergoing surgery before 7 months of age. Our study showed that IOL implantation is relatively safe in children older than 6 months and younger than 2 years.

Original languageEnglish (US)
StatePublished - Jan 1 2019


ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bothun, E. D., Wilson, M. E., Traboulsi, E. I., Diehl, N. N., Plager, D. A., Vanderveen, D. K., Freedman, S. F., Yen, K. G., Weil, N. C., Loh, A., Morrison, D., Anderson, J. S., Lambert, S. R., Lambert, S., Hutchinson, A., Christiansen, S., Bothun, E., Wilson, E., Traboulsi, E., ... Wheeler, D. (2019). Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS). Ophthalmology. https://doi.org/10.1016/j.ophtha.2019.03.011