Outcomes of Hematologic Malignancies after Unrelated Donor Hematopoietic Cell Transplantation According to Place of Residence

Fausto R. Loberiza, Stephanie J. Lee, John P. Klein, Anna Hassebroek, Jason G. Dehn, Haydar A. Frangoul, Theresa Hahn, Gregory Hale, Hillard M. Lazarus, Charles F. LeMaistre, Richard Maziarz, J. Douglas Rizzo, Navneet S. Majhail

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Studies suggest that patients who live in rural areas may have worse clinical outcomes compared with patients living in urban areas. We studied whether place of residence (rural versus urban) is associated with clinical outcomes of patients with leukemia or myelodysplastic syndrome (MDS) who received an unrelated donor hematopoietic cell transplantation (HCT). Patients' residential ZIP code at the time of transplant was used to determine rural or urban designation based on the Rural Urban Commuting Codes. The study included 6140 patients reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 121 U.S. HCT centers: 1179 (19%) came from rural areas, whereas 4961 (81%) came from urban areas. Rural and urban patients were similar in patient-, disease-, and transplant-related characteristics aside from household income and distance traveled to the HCT center. After adjusting for income and other significant patient, disease, and transplant-related variables, the risk of overall mortality between patients residing in rural and urban areas were not statistically significant (relative risk 1.01, 95% confidence intervals 0.93-1.10, P = .74). Similar outcomes were noted for treatment-related mortality (TRM), disease-free survival (DFS), and relapse. Patient's income, derived from the U.S. Census and based on their residential ZIP code, was independently associated with outcomes. In summary, our study showed no differences in the clinical outcomes of patients from rural or urban areas after unrelated donor HCT.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Unrelated Donors
Cell Transplantation
Hematologic Neoplasms
Transplants
Mortality
Myelodysplastic Syndromes
Censuses
Disease-Free Survival
Leukemia
Bone Marrow
Confidence Intervals

Keywords

  • Rural
  • Socioeconomic status
  • Unrelated donor hematopoietic cell transplantation

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Outcomes of Hematologic Malignancies after Unrelated Donor Hematopoietic Cell Transplantation According to Place of Residence. / Loberiza, Fausto R.; Lee, Stephanie J.; Klein, John P.; Hassebroek, Anna; Dehn, Jason G.; Frangoul, Haydar A.; Hahn, Theresa; Hale, Gregory; Lazarus, Hillard M.; LeMaistre, Charles F.; Maziarz, Richard; Rizzo, J. Douglas; Majhail, Navneet S.

In: Biology of Blood and Marrow Transplantation, Vol. 16, No. 3, 03.2010, p. 368-375.

Research output: Contribution to journalArticle

Loberiza, FR, Lee, SJ, Klein, JP, Hassebroek, A, Dehn, JG, Frangoul, HA, Hahn, T, Hale, G, Lazarus, HM, LeMaistre, CF, Maziarz, R, Rizzo, JD & Majhail, NS 2010, 'Outcomes of Hematologic Malignancies after Unrelated Donor Hematopoietic Cell Transplantation According to Place of Residence', Biology of Blood and Marrow Transplantation, vol. 16, no. 3, pp. 368-375. https://doi.org/10.1016/j.bbmt.2009.10.028
Loberiza, Fausto R. ; Lee, Stephanie J. ; Klein, John P. ; Hassebroek, Anna ; Dehn, Jason G. ; Frangoul, Haydar A. ; Hahn, Theresa ; Hale, Gregory ; Lazarus, Hillard M. ; LeMaistre, Charles F. ; Maziarz, Richard ; Rizzo, J. Douglas ; Majhail, Navneet S. / Outcomes of Hematologic Malignancies after Unrelated Donor Hematopoietic Cell Transplantation According to Place of Residence. In: Biology of Blood and Marrow Transplantation. 2010 ; Vol. 16, No. 3. pp. 368-375.
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