TY - JOUR
T1 - Osteoclastogenesis
T2 - The role of calcium and calmodulin
AU - Zhang, Liang
AU - Said-Al-Naief, Nasser
AU - Feng, Xu
AU - McDonald, Jay M.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - Enhanced osteoclastogenesis is an important pathological feature in several aging-associated bone diseases. Thus, research activities on osteoclastogenesis have been intense during the last ten years. There has been great progress made in this field, however, and in this review, we will focus on current advances in understanding the role of Ca2+/calmodulin signaling in osteoclastogenesis. There are two major Ca2+/calmodulin signaling pathways emerging as important in osteoclastogenesis. The first is from our recent data, which has established a specific role for calmodulin in osteoclastogenesis and, more specifically, calmodulin-dependent kinase II (CaMKII). The other is that a pathway involving RANK-Ca2+-calmodulin- calcineurin-NFAT is critical for osteoclastogenesis. Collectively, these reports highlight the importance of Ca2+/calmodulin signaling in osteoclastogenesis, which may present novel targets for the new therapeutic agents to combat bone loss.
AB - Enhanced osteoclastogenesis is an important pathological feature in several aging-associated bone diseases. Thus, research activities on osteoclastogenesis have been intense during the last ten years. There has been great progress made in this field, however, and in this review, we will focus on current advances in understanding the role of Ca2+/calmodulin signaling in osteoclastogenesis. There are two major Ca2+/calmodulin signaling pathways emerging as important in osteoclastogenesis. The first is from our recent data, which has established a specific role for calmodulin in osteoclastogenesis and, more specifically, calmodulin-dependent kinase II (CaMKII). The other is that a pathway involving RANK-Ca2+-calmodulin- calcineurin-NFAT is critical for osteoclastogenesis. Collectively, these reports highlight the importance of Ca2+/calmodulin signaling in osteoclastogenesis, which may present novel targets for the new therapeutic agents to combat bone loss.
KW - Calmodulin
KW - Differentiation
KW - Osteoclast
KW - Signal transduction
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U2 - 10.1615/CritRevEukarGeneExpr.v15.i1.10
DO - 10.1615/CritRevEukarGeneExpr.v15.i1.10
M3 - Review article
C2 - 15831075
AN - SCOPUS:18844452949
SN - 1045-4403
VL - 15
SP - 1
EP - 13
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 1
ER -