Ornithine Decarboxylase and Polyamines in Colorectal Neoplasia and Mucosa

Lee J. Hixson, Harinder S. Garewal, Daniel L. McGee, Donna Sloan, M. Brian Fennerty, Richard E. Sampliner, Eugene W. Gerner

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Ornithine decarboxylase (ODC) and polyamines are intimately involved in normal cellular proliferation and are likely to play a role in carcinogenesis. ODC activity and polyamine content were measured in tissue samples obtained during colonoscopy from 48 benign neoplastic polyps (20 tubular adenomas; 28 villous adenomas), 18 cancers (including 5 malignant polyps), and adjacent mucosa. ODC activity in polyp and cancer tissue specimens was higher than in adjacent mucosa in 75 and 83% of pairs, respectively. Similarly, putrescine, spermidine, and spermine contents were higher in the majority of polyps and cancers compared to adjacent mucosa. ODC activity and polyamine content in colonic mucosa from 10 patients without a history of colorectal neoplasia were not different from adjacent mucosal values in the patients with neoplasia. In conclusion, ODC and polyamines are elevated in the majority of colorectal neoplasms, but amounts in normal mucosa do not differentiate between patients with cancer, benign neoplastic polyps, and normal subjects.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume2
Issue number4
StatePublished - Jul 1 1993

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Hixson, L. J., Garewal, H. S., McGee, D. L., Sloan, D., Fennerty, M. B., Sampliner, R. E., & Gerner, E. W. (1993). Ornithine Decarboxylase and Polyamines in Colorectal Neoplasia and Mucosa. Cancer Epidemiology Biomarkers and Prevention, 2(4), 369-374.