TY - JOUR
T1 - Oral therapy with ketoconazole for dermatophyte infections unresponsive to griseofulvin.
AU - Robertson, M. H.
AU - Hanifin, J. M.
AU - Parker, F.
PY - 1980
Y1 - 1980
N2 - Oral ketoconazole therapy was evaluated with 21 patients who had recalcitrant dermatophytosis. During an 18-week period, all patients, including three with organisms resistant to griseofulvin in vitro, showed impressive clinical improvement. The four patients without nail involvement became mycologically negative earlier than those with onychomycosis. The latter group showed progressive clearing of the nails, but only three were mycologically clear after 18 weeks. Adverse reactions to ketoconazole were negligible, and no patients required discontinuance of the drug. Ketoconazole appears to be a safe, effective drug for oral therapy of dermatophytoses in humans.
AB - Oral ketoconazole therapy was evaluated with 21 patients who had recalcitrant dermatophytosis. During an 18-week period, all patients, including three with organisms resistant to griseofulvin in vitro, showed impressive clinical improvement. The four patients without nail involvement became mycologically negative earlier than those with onychomycosis. The latter group showed progressive clearing of the nails, but only three were mycologically clear after 18 weeks. Adverse reactions to ketoconazole were negligible, and no patients required discontinuance of the drug. Ketoconazole appears to be a safe, effective drug for oral therapy of dermatophytoses in humans.
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U2 - 10.1093/clinids/2.4.578
DO - 10.1093/clinids/2.4.578
M3 - Article
C2 - 6255533
AN - SCOPUS:0019043422
SN - 0162-0886
VL - 2
SP - 578
EP - 581
JO - Reviews of infectious diseases
JF - Reviews of infectious diseases
IS - 4
ER -