Oral self administration of ethanol in free feeding rats

Kathleen (Kathy) Grant, Herman H. Samson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The use of animal models to study factors involved in excessive alcohol intake has prompted a number of investigators to propose criteria for an optimal model. One of these criterion, oral ingestion of intoxicating amounts of ethanol without concomitant weight loss and/or food restriction, has proven difficult to fulfill, especially when using rats. The following study reports a conditioning paradigm which was used to establish oral ethanol self administration in free feeding rats. Through initial reinforcement of 5% (v/v) ethanol consumption with 20% (w/v) sucrose solution, rats were trained to work for and consume concentrations of ethanol up to and including 40%. Blood ethanol levels above 100 mg ethanol/dl blood were frequently found. A control group, induced to drink quinine with the same procedures, indicated the relative importance of ethanol's pharmacological effect in maintaining high levels of self administration. The results show ethanol can maintain oral self administration of intoxicating quantities of high ethanol concentrations in free feeding rats, when its initial consumption is paired with an additional reinforcer.

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalAlcohol
Volume2
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

self-administration
Self Administration
Oral Administration
Rats
Ethanol
conditioning
reinforcement
animal
alcohol
paradigm
food
Blood
Quinine
Group
Sucrose
Weight Loss
Reinforcement
Animals
Animal Models
Eating

Keywords

  • Alcohol self administration
  • Animal models
  • Operant conditioning
  • Rats

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Oral self administration of ethanol in free feeding rats. / Grant, Kathleen (Kathy); Samson, Herman H.

In: Alcohol, Vol. 2, No. 2, 1985, p. 317-321.

Research output: Contribution to journalArticle

Grant, Kathleen (Kathy) ; Samson, Herman H. / Oral self administration of ethanol in free feeding rats. In: Alcohol. 1985 ; Vol. 2, No. 2. pp. 317-321.
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