Optimizing synaptic architecture and efficiency for high-frequency transmission

Holger Taschenberger, Ricardo M. Leão, Kevin C. Rowland, George A. Spirou, Henrique Von Gersdorff

Research output: Contribution to journalArticle

262 Citations (Scopus)

Abstract

Bursts of neuronal activity are transmitted more effectively as synapses mature. However, the mechanisms that control synaptic efficiency during development are poorly understood. Here, we study postnatal changes in synaptic ultrastructure and exocytosis in a calyx-type nerve terminal. Vesicle pool size, exocytotic efficiency (amount of exocytosis per Ca influx), Ca current facilitation, and the number of active zones (AZs) increased with age, whereas AZ area, number of docked vesicles per AZ, and release probability decreased with age. These changes led to AZs that are less prone to multivesicular release, resulting in reduced AMPA receptor saturation and desensitization. A greater multiplicity of small AZs with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release thus promote prolonged high-frequency firing in mature synapses.

Original languageEnglish (US)
Pages (from-to)1127-1143
Number of pages17
JournalNeuron
Volume36
Issue number6
DOIs
StatePublished - Dec 19 2002

Fingerprint

Exocytosis
Synapses
AMPA Receptors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Optimizing synaptic architecture and efficiency for high-frequency transmission. / Taschenberger, Holger; Leão, Ricardo M.; Rowland, Kevin C.; Spirou, George A.; Von Gersdorff, Henrique.

In: Neuron, Vol. 36, No. 6, 19.12.2002, p. 1127-1143.

Research output: Contribution to journalArticle

Taschenberger, Holger ; Leão, Ricardo M. ; Rowland, Kevin C. ; Spirou, George A. ; Von Gersdorff, Henrique. / Optimizing synaptic architecture and efficiency for high-frequency transmission. In: Neuron. 2002 ; Vol. 36, No. 6. pp. 1127-1143.
@article{ca6a96ec24e94d718bc1c36c3236a420,
title = "Optimizing synaptic architecture and efficiency for high-frequency transmission",
abstract = "Bursts of neuronal activity are transmitted more effectively as synapses mature. However, the mechanisms that control synaptic efficiency during development are poorly understood. Here, we study postnatal changes in synaptic ultrastructure and exocytosis in a calyx-type nerve terminal. Vesicle pool size, exocytotic efficiency (amount of exocytosis per Ca influx), Ca current facilitation, and the number of active zones (AZs) increased with age, whereas AZ area, number of docked vesicles per AZ, and release probability decreased with age. These changes led to AZs that are less prone to multivesicular release, resulting in reduced AMPA receptor saturation and desensitization. A greater multiplicity of small AZs with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release thus promote prolonged high-frequency firing in mature synapses.",
author = "Holger Taschenberger and Le{\~a}o, {Ricardo M.} and Rowland, {Kevin C.} and Spirou, {George A.} and {Von Gersdorff}, Henrique",
year = "2002",
month = "12",
day = "19",
doi = "10.1016/S0896-6273(02)01137-6",
language = "English (US)",
volume = "36",
pages = "1127--1143",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Optimizing synaptic architecture and efficiency for high-frequency transmission

AU - Taschenberger, Holger

AU - Leão, Ricardo M.

AU - Rowland, Kevin C.

AU - Spirou, George A.

AU - Von Gersdorff, Henrique

PY - 2002/12/19

Y1 - 2002/12/19

N2 - Bursts of neuronal activity are transmitted more effectively as synapses mature. However, the mechanisms that control synaptic efficiency during development are poorly understood. Here, we study postnatal changes in synaptic ultrastructure and exocytosis in a calyx-type nerve terminal. Vesicle pool size, exocytotic efficiency (amount of exocytosis per Ca influx), Ca current facilitation, and the number of active zones (AZs) increased with age, whereas AZ area, number of docked vesicles per AZ, and release probability decreased with age. These changes led to AZs that are less prone to multivesicular release, resulting in reduced AMPA receptor saturation and desensitization. A greater multiplicity of small AZs with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release thus promote prolonged high-frequency firing in mature synapses.

AB - Bursts of neuronal activity are transmitted more effectively as synapses mature. However, the mechanisms that control synaptic efficiency during development are poorly understood. Here, we study postnatal changes in synaptic ultrastructure and exocytosis in a calyx-type nerve terminal. Vesicle pool size, exocytotic efficiency (amount of exocytosis per Ca influx), Ca current facilitation, and the number of active zones (AZs) increased with age, whereas AZ area, number of docked vesicles per AZ, and release probability decreased with age. These changes led to AZs that are less prone to multivesicular release, resulting in reduced AMPA receptor saturation and desensitization. A greater multiplicity of small AZs with few docked vesicles, a larger pool of releasable vesicles, and a higher efficiency of release thus promote prolonged high-frequency firing in mature synapses.

UR - http://www.scopus.com/inward/record.url?scp=0037137693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037137693&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(02)01137-6

DO - 10.1016/S0896-6273(02)01137-6

M3 - Article

VL - 36

SP - 1127

EP - 1143

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -