Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal

James H. O'Keefe, Loren Cordain, William H. Harris, Richard M. Moe, Robert Vogel

Research output: Contribution to journalReview articlepeer-review

360 Scopus citations

Abstract

The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.

Original languageEnglish (US)
Pages (from-to)2142-2146
Number of pages5
JournalJournal of the American College of Cardiology
Volume43
Issue number11
DOIs
StatePublished - Jun 2 2004

Keywords

  • CHD
  • LDL
  • NCEP-ATP-III
  • Natural Cholesterol Education Program-Adult Treatment Panel-III
  • coronary heart disease
  • low density lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal'. Together they form a unique fingerprint.

Cite this