Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal

James H. O'Keefe; Loren Cordain; William H. Harris; Richard M. Moe; Robert Vogel

doi:10.1016/j.jacc.2004.03.046

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal

James H. O'Keefe, Loren Cordain, William H. Harris, Richard M. Moe, Robert Vogel

Research output: Contribution to journal › Review article › peer-review

418 Scopus citations

Abstract

The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.

Original language	English (US)
Pages (from-to)	2142-2146
Number of pages	5
Journal	Journal of the American College of Cardiology
Volume	43
Issue number	11
DOIs	https://doi.org/10.1016/j.jacc.2004.03.046
State	Published - Jun 2 2004
Externally published	Yes

Keywords

CHD
LDL
NCEP-ATP-III
Natural Cholesterol Education Program-Adult Treatment Panel-III
coronary heart disease
low density lipoprotein

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacc.2004.03.046

Cite this

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title = "Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal",

abstract = "The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.",

keywords = "CHD, LDL, NCEP-ATP-III, Natural Cholesterol Education Program-Adult Treatment Panel-III, coronary heart disease, low density lipoprotein",

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year = "2004",

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T2 - Lower is better and physiologically normal

AU - O'Keefe, James H.

AU - Cordain, Loren

AU - Harris, William H.

AU - Moe, Richard M.

AU - Vogel, Robert

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AB - The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.

KW - CHD

KW - LDL

KW - NCEP-ATP-III

KW - Natural Cholesterol Education Program-Adult Treatment Panel-III

KW - coronary heart disease

KW - low density lipoprotein

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Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal

Abstract

Keywords

ASJC Scopus subject areas

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