Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact

Yali Jia, Ruikang K. Wang

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Alteration in regional cerebral blood flow (CBF) is the direct result of changes in neuronal activity. It is crucial to monitor the spatio-temporal characteristics of cerebro-vascular blood perfusion in the studies of cerebral diseases. Optical micro-angiography (OMAG) is a recently developed imaging technique capable of resolving 3D distribution of dynamic blood perfusion at a capillary level resolution within microcirculatory beds in vivo. The authors report the applications of OMAG in mouse ischemic stroke model. The study demonstrates that OMAG is a useful method capable of providing in vivo serial assessment of 3D cerebro-vascular pathophysiology with high sensitivity, and therefore, has the potential for use in the study of brain disorders and repairs.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalJournal of Biophotonics
Volume4
Issue number1-2
DOIs
StatePublished - Jan 2011

Keywords

  • Cerebro-vascular blood perfusion
  • Ischemic stroke
  • Optical micro-angiography (OMAG)

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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