Optical imaging of short-term working memory in prefrontal cortex of the Macaque monkey

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Prefrontal cortex is an area critical for cognitive functions such as planning, decision-making, and reasoning. Working memory is a key aspect to the execution of these functions and has been strongly associated with prefrontal function. This chapter reviews the functional organization of a prefrontal area, area 46, that has been associated with working memory in monkeys. Anatomical and optical imaging studies indicate the presence of a clustered organization within area 46, similar in nature to clustered organizations found in sensory cortical areas. Although the relationship of these clusters to working memory function is unknown, optical imaging studies suggest a spatial organization for mnemonic function. This 'spatial memory map' is topographically consistent with electrophysiologically established maps for visual and eye movement response. Interestingly, in trials in which response suppression is required, optical imaging reveals a possible suppressive signal; lack of this signal may underly the perseveration seen in diseases such as schizophrenia. In sum, I suggest that clustered organization in prefrontal cortex provides a scaffold upon which visual, mnemonic, and motor response are organized.

Original languageEnglish (US)
Title of host publicationImaging the Brain with Optical Methods
PublisherSpringer New York
Pages119-133
Number of pages15
ISBN (Print)9781441904522, 9781441904515
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Optical Imaging
Macaca
Prefrontal Cortex
Short-Term Memory
Haplorhini
Eye Movements
Cognition
Schizophrenia
Decision Making
Spatial Memory

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Optical imaging of short-term working memory in prefrontal cortex of the Macaque monkey. / Roe, Anna.

Imaging the Brain with Optical Methods. Springer New York, 2010. p. 119-133.

Research output: Chapter in Book/Report/Conference proceedingChapter

Roe, Anna. / Optical imaging of short-term working memory in prefrontal cortex of the Macaque monkey. Imaging the Brain with Optical Methods. Springer New York, 2010. pp. 119-133
@inbook{9474913868d5421b983c2163e389171d,
title = "Optical imaging of short-term working memory in prefrontal cortex of the Macaque monkey",
abstract = "Prefrontal cortex is an area critical for cognitive functions such as planning, decision-making, and reasoning. Working memory is a key aspect to the execution of these functions and has been strongly associated with prefrontal function. This chapter reviews the functional organization of a prefrontal area, area 46, that has been associated with working memory in monkeys. Anatomical and optical imaging studies indicate the presence of a clustered organization within area 46, similar in nature to clustered organizations found in sensory cortical areas. Although the relationship of these clusters to working memory function is unknown, optical imaging studies suggest a spatial organization for mnemonic function. This 'spatial memory map' is topographically consistent with electrophysiologically established maps for visual and eye movement response. Interestingly, in trials in which response suppression is required, optical imaging reveals a possible suppressive signal; lack of this signal may underly the perseveration seen in diseases such as schizophrenia. In sum, I suggest that clustered organization in prefrontal cortex provides a scaffold upon which visual, mnemonic, and motor response are organized.",
author = "Anna Roe",
year = "2010",
doi = "10.1007/978-1-4419-0452-2_6",
language = "English (US)",
isbn = "9781441904522",
pages = "119--133",
booktitle = "Imaging the Brain with Optical Methods",
publisher = "Springer New York",

}

TY - CHAP

T1 - Optical imaging of short-term working memory in prefrontal cortex of the Macaque monkey

AU - Roe, Anna

PY - 2010

Y1 - 2010

N2 - Prefrontal cortex is an area critical for cognitive functions such as planning, decision-making, and reasoning. Working memory is a key aspect to the execution of these functions and has been strongly associated with prefrontal function. This chapter reviews the functional organization of a prefrontal area, area 46, that has been associated with working memory in monkeys. Anatomical and optical imaging studies indicate the presence of a clustered organization within area 46, similar in nature to clustered organizations found in sensory cortical areas. Although the relationship of these clusters to working memory function is unknown, optical imaging studies suggest a spatial organization for mnemonic function. This 'spatial memory map' is topographically consistent with electrophysiologically established maps for visual and eye movement response. Interestingly, in trials in which response suppression is required, optical imaging reveals a possible suppressive signal; lack of this signal may underly the perseveration seen in diseases such as schizophrenia. In sum, I suggest that clustered organization in prefrontal cortex provides a scaffold upon which visual, mnemonic, and motor response are organized.

AB - Prefrontal cortex is an area critical for cognitive functions such as planning, decision-making, and reasoning. Working memory is a key aspect to the execution of these functions and has been strongly associated with prefrontal function. This chapter reviews the functional organization of a prefrontal area, area 46, that has been associated with working memory in monkeys. Anatomical and optical imaging studies indicate the presence of a clustered organization within area 46, similar in nature to clustered organizations found in sensory cortical areas. Although the relationship of these clusters to working memory function is unknown, optical imaging studies suggest a spatial organization for mnemonic function. This 'spatial memory map' is topographically consistent with electrophysiologically established maps for visual and eye movement response. Interestingly, in trials in which response suppression is required, optical imaging reveals a possible suppressive signal; lack of this signal may underly the perseveration seen in diseases such as schizophrenia. In sum, I suggest that clustered organization in prefrontal cortex provides a scaffold upon which visual, mnemonic, and motor response are organized.

UR - http://www.scopus.com/inward/record.url?scp=83055168746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83055168746&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-0452-2_6

DO - 10.1007/978-1-4419-0452-2_6

M3 - Chapter

AN - SCOPUS:83055168746

SN - 9781441904522

SN - 9781441904515

SP - 119

EP - 133

BT - Imaging the Brain with Optical Methods

PB - Springer New York

ER -