Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography

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Abstract

Purpose To evaluate the morphological structure of illdefined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En face OCT angiograms were compared with FA. Results Eleven cases of ill-defined CNV on FA were identified from 10 study participants. Mean age of the participants was 74.5±6.8 years. Six cases had late leakage from undetermined source (LLUS) and five had fibrovascular pigment epithelial detachment (FVPED). Combining cross-sectional structural OCT with OCT angiograms, all cases were found to have type 1 CNV that corresponded to occult CNV with FA. In all cases of occult CNV on FA, distinct vascular structures were visible with OCTA in the outer retinal/retinal pigment epithelium slab. The mean CNV vessel area was 2.61 ±3.65 mm2. The mean CNV vessel area in cases with FVPED was larger than that in cases with LLUS (4.69 ±4.72 mm2 compared with 0.85±0.90 mm2, Mann- Whitney p value=0.04). Conclusions Although the sample size is small to draw conclusions and the nature of work is retrospective and descriptive, OCTA has the potential to improve visualisation of ill-defined CNV with dye-based angiography, including occult CNV.

Original languageEnglish (US)
JournalBritish Journal of Ophthalmology
DOIs
StateAccepted/In press - Dec 1 2016

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Choroidal Neovascularization
Fluorescein Angiography
Angiography
Optical Coherence Tomography
Retinal Pigment Epithelium
Sample Size
Blood Vessels
Coloring Agents

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

@article{600f97b5b1614b3aa2d5a40b30a3271f,
title = "Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography",
abstract = "Purpose To evaluate the morphological structure of illdefined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En face OCT angiograms were compared with FA. Results Eleven cases of ill-defined CNV on FA were identified from 10 study participants. Mean age of the participants was 74.5±6.8 years. Six cases had late leakage from undetermined source (LLUS) and five had fibrovascular pigment epithelial detachment (FVPED). Combining cross-sectional structural OCT with OCT angiograms, all cases were found to have type 1 CNV that corresponded to occult CNV with FA. In all cases of occult CNV on FA, distinct vascular structures were visible with OCTA in the outer retinal/retinal pigment epithelium slab. The mean CNV vessel area was 2.61 ±3.65 mm2. The mean CNV vessel area in cases with FVPED was larger than that in cases with LLUS (4.69 ±4.72 mm2 compared with 0.85±0.90 mm2, Mann- Whitney p value=0.04). Conclusions Although the sample size is small to draw conclusions and the nature of work is retrospective and descriptive, OCTA has the potential to improve visualisation of ill-defined CNV with dye-based angiography, including occult CNV.",
author = "Mehrdad Malihi and Jia Yali and Gao, {Simon S.} and Christina Flaxel and Lauer, {Andreas (Andy)} and Thomas Hwang and David Wilson and David Huang and Steven Bailey",
year = "2016",
month = "12",
day = "1",
doi = "10.1136/bjophthalmol-2016-309094",
language = "English (US)",
journal = "British Journal of Ophthalmology",
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T1 - Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography

AU - Malihi, Mehrdad

AU - Yali, Jia

AU - Gao, Simon S.

AU - Flaxel, Christina

AU - Lauer, Andreas (Andy)

AU - Hwang, Thomas

AU - Wilson, David

AU - Huang, David

AU - Bailey, Steven

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose To evaluate the morphological structure of illdefined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En face OCT angiograms were compared with FA. Results Eleven cases of ill-defined CNV on FA were identified from 10 study participants. Mean age of the participants was 74.5±6.8 years. Six cases had late leakage from undetermined source (LLUS) and five had fibrovascular pigment epithelial detachment (FVPED). Combining cross-sectional structural OCT with OCT angiograms, all cases were found to have type 1 CNV that corresponded to occult CNV with FA. In all cases of occult CNV on FA, distinct vascular structures were visible with OCTA in the outer retinal/retinal pigment epithelium slab. The mean CNV vessel area was 2.61 ±3.65 mm2. The mean CNV vessel area in cases with FVPED was larger than that in cases with LLUS (4.69 ±4.72 mm2 compared with 0.85±0.90 mm2, Mann- Whitney p value=0.04). Conclusions Although the sample size is small to draw conclusions and the nature of work is retrospective and descriptive, OCTA has the potential to improve visualisation of ill-defined CNV with dye-based angiography, including occult CNV.

AB - Purpose To evaluate the morphological structure of illdefined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En face OCT angiograms were compared with FA. Results Eleven cases of ill-defined CNV on FA were identified from 10 study participants. Mean age of the participants was 74.5±6.8 years. Six cases had late leakage from undetermined source (LLUS) and five had fibrovascular pigment epithelial detachment (FVPED). Combining cross-sectional structural OCT with OCT angiograms, all cases were found to have type 1 CNV that corresponded to occult CNV with FA. In all cases of occult CNV on FA, distinct vascular structures were visible with OCTA in the outer retinal/retinal pigment epithelium slab. The mean CNV vessel area was 2.61 ±3.65 mm2. The mean CNV vessel area in cases with FVPED was larger than that in cases with LLUS (4.69 ±4.72 mm2 compared with 0.85±0.90 mm2, Mann- Whitney p value=0.04). Conclusions Although the sample size is small to draw conclusions and the nature of work is retrospective and descriptive, OCTA has the potential to improve visualisation of ill-defined CNV with dye-based angiography, including occult CNV.

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