Optical assessment of tissue heterogeneity in biomaterials and implants

Steven L. Jacques

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


Optical techniques can assess the heterogeneity and structural layers of biomaterials and implants. Such assessment can assist engineering of tissue patches and implants by assessing implant structure, monitoring the implant fabrication process, controlling the machining of the implant, and monitoring in vivo the body's host response to the implant. Optical scattering can quantify the granularity of a biomaterial on the scale of 0.1-10 μm. Optical coherence tomography can map heterogeneity on the scale of 2-20 μm. Optoacoustic imaging can image absorbing heterogeneities on the scale of 20 μm - 10 mm (or more). Diffusion optical tomography can image absorbing and scattering heterogeneities on the scale of 5 mm - 5 cm (or more). The opportunities for optical techniques in preparing biomaterials and implants are discussed.

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 2000
EventLaser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical - San Jose, CA, USA
Duration: Jan 22 2000Jan 27 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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