Optical assessment of cutaneous blood volume depends on the vessel size distribution

A computer simulation study

Steven Jacques

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A Monte Carlo simulation was adapted to specify a skin model with pigmented epidermis, dermis with low baseline blood content, and vessels of a vascular lesion with an average added blood volume fraction of 5%. In the study, the lesion vessel diameters were increased and the number of lesion vessels decreased, such that the total lesion blood content was constant. The results show that reflectance (R) increases as vessel size increases, even though the blood content is constant. Light cannot penetrate effectively into larger blood vessels, so the interior of the vessel becomes less visible to the light - a result known in the literature. This study did repeated random placement of vessels to learn the variation in R due to variable vessel placement. The coefficient of variation was about 10% due to random placement. R varies with size, even with small vessels, and does not simply apply to large vessels.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalJournal of Biophotonics
Volume3
Issue number1-2
DOIs
StatePublished - 2010

Fingerprint

blood volume
Blood Volume
Computer Simulation
vessels
Blood Vessels
Blood
computerized simulation
Skin
Computer simulation
Light
lesions
Dermis
Epidermis
blood
Blood vessels
Volume fraction
epidermis
blood vessels
reflectance

Keywords

  • Blood vessels
  • Monte Carlo simulation
  • Optical measurement
  • Reflectance

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Optical assessment of cutaneous blood volume depends on the vessel size distribution : A computer simulation study. / Jacques, Steven.

In: Journal of Biophotonics, Vol. 3, No. 1-2, 2010, p. 75-81.

Research output: Contribution to journalArticle

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