Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones

R. A. North, John Williams

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Opiates act on μ-receptors to increase the potassium conductance of the rat locus coeruleus neurones. Opiates also depress the rate of rise and peak amplitude of calcium action potentials in these cells. The action of opiates of calcium action potentials was prevented by two procedures which blocked the opiate-induced potassium current, intracellular caesium and extracellular barium. This indicates that the opiate reduction in calcium entry is secondary to an increased potassium current.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalBritish Journal of Pharmacology
Volume80
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Opiate Alkaloids
Locus Coeruleus
Action Potentials
Potassium
Calcium
Neurons
Cesium
Barium

ASJC Scopus subject areas

  • Pharmacology

Cite this

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones. / North, R. A.; Williams, John.

In: British Journal of Pharmacology, Vol. 80, No. 2, 1983, p. 225-228.

Research output: Contribution to journalArticle

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