On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy

Peter Spencer, Monica C. Bischoff, Herbert H. Schaumburg

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Abstract

A total of 56 young rats were fed 10 different hydrocarbon derivatives to determine the molecular configuration required for the production of nervous system disease of the type characterized by giant axonal degeneration in the distal regions of long and large, central and peripheral nerve fibers (central-peripheral distal axonopathy). For periods up to 14 weeks, animals drank ad libitum aqueous solutions containing 0.5% 2-heptanone, 0.5% 3,5-heptanedione, 0.5% 2,5-hexanedione, 0.5% 2,5-hexanediol, 0.5% 2,4-hexanedione, 0.5% 2,3-hexanedione, 0.5% 1,6-hexanediol, 0.5% 1,4-butanediol, 0.05, 0.1, or 0.25% glutaraldehyde, and 0.5 or 1% acetone. Animals treated with 2,5-hexanedione or 2,5-hexanediol failed to gain weight normally and slowly developed hindlimb weakness typical of a symmetrical peripheral neuropathy. Pathological examination of these animals revealed giant axonal swelling and secondary myelin changes in the distal regions of (1) the spino-cerebellar tracts in the cerebellar vermis and medulla oblongata, (2) the dorsal columns of the cervical, thoracic, and upper lumbar spinal cord, and (3) the sciatic, tibial, and plantar nerves. These characteristic clinical and pathological features of central-peripheral distal axonopathy failed to develop in the other groups of rats.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalToxicology and Applied Pharmacology
Volume44
Issue number1
DOIs
StatePublished - 1978
Externally publishedYes

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Molecular Conformation
Animals
Rats
Spinal Cord
Tibial Nerve
Medulla Oblongata
Neurology
Glutaral
Peripheral Nervous System Diseases
Hindlimb
Myelin Sheath
Hydrocarbons
Acetone
Nervous System Diseases
Peripheral Nerves
Nerve Fibers
Weight Gain
Swelling
Thorax
Derivatives

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy. / Spencer, Peter; Bischoff, Monica C.; Schaumburg, Herbert H.

In: Toxicology and Applied Pharmacology, Vol. 44, No. 1, 1978, p. 17-28.

Research output: Contribution to journalArticle

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