Omega-3 Fatty Acids and Risk for Cardiovascular Disease

William Harris, C. von Schacky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The long-chain marine n-3 fatty acids have been reported to be cardio protective over many years and many mechanisms of action have been proposed. Up through the first decade of the 21st century, nearly all n-3 randomized trials were positive, but beginning in 2010 several trials were published that did not show a benefit of these fatty acids on clinical cardiovascular endpoints. There is a wealth of epidemiologic evidence for a cardiac benefit for the n-3 fatty acids that appears to contradict the findings of the randomized trials. This chapter will review both trial and prospective cohort study data which, in the aggregate, continues to support the view that n-3 fatty acids are heart healthy.

Original languageEnglish (US)
Title of host publicationFish and Fish Oil in Health and Disease Prevention
PublisherElsevier Inc.
Pages199-205
Number of pages7
ISBN (Print)9780128028445
DOIs
StatePublished - Jul 27 2016
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Cardiovascular Diseases
Cohort Studies
Fatty Acids
Prospective Studies

Keywords

  • Cardiovascular disease
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fish oil
  • N-3 fatty acids
  • Prospective cohort studies
  • Randomized trials

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

Cite this

Harris, W., & von Schacky, C. (2016). Omega-3 Fatty Acids and Risk for Cardiovascular Disease. In Fish and Fish Oil in Health and Disease Prevention (pp. 199-205). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802844-5.00018-X

Omega-3 Fatty Acids and Risk for Cardiovascular Disease. / Harris, William; von Schacky, C.

Fish and Fish Oil in Health and Disease Prevention. Elsevier Inc., 2016. p. 199-205.

Research output: Chapter in Book/Report/Conference proceedingChapter

Harris, W & von Schacky, C 2016, Omega-3 Fatty Acids and Risk for Cardiovascular Disease. in Fish and Fish Oil in Health and Disease Prevention. Elsevier Inc., pp. 199-205. https://doi.org/10.1016/B978-0-12-802844-5.00018-X
Harris W, von Schacky C. Omega-3 Fatty Acids and Risk for Cardiovascular Disease. In Fish and Fish Oil in Health and Disease Prevention. Elsevier Inc. 2016. p. 199-205 https://doi.org/10.1016/B978-0-12-802844-5.00018-X
Harris, William ; von Schacky, C. / Omega-3 Fatty Acids and Risk for Cardiovascular Disease. Fish and Fish Oil in Health and Disease Prevention. Elsevier Inc., 2016. pp. 199-205
@inbook{4d4596d7fcc24a9387ce6f9ba7a03ed5,
title = "Omega-3 Fatty Acids and Risk for Cardiovascular Disease",
abstract = "The long-chain marine n-3 fatty acids have been reported to be cardio protective over many years and many mechanisms of action have been proposed. Up through the first decade of the 21st century, nearly all n-3 randomized trials were positive, but beginning in 2010 several trials were published that did not show a benefit of these fatty acids on clinical cardiovascular endpoints. There is a wealth of epidemiologic evidence for a cardiac benefit for the n-3 fatty acids that appears to contradict the findings of the randomized trials. This chapter will review both trial and prospective cohort study data which, in the aggregate, continues to support the view that n-3 fatty acids are heart healthy.",
keywords = "Cardiovascular disease, Docosahexaenoic acid, Eicosapentaenoic acid, Fish oil, N-3 fatty acids, Prospective cohort studies, Randomized trials",
author = "William Harris and {von Schacky}, C.",
year = "2016",
month = "7",
day = "27",
doi = "10.1016/B978-0-12-802844-5.00018-X",
language = "English (US)",
isbn = "9780128028445",
pages = "199--205",
booktitle = "Fish and Fish Oil in Health and Disease Prevention",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Omega-3 Fatty Acids and Risk for Cardiovascular Disease

AU - Harris, William

AU - von Schacky, C.

PY - 2016/7/27

Y1 - 2016/7/27

N2 - The long-chain marine n-3 fatty acids have been reported to be cardio protective over many years and many mechanisms of action have been proposed. Up through the first decade of the 21st century, nearly all n-3 randomized trials were positive, but beginning in 2010 several trials were published that did not show a benefit of these fatty acids on clinical cardiovascular endpoints. There is a wealth of epidemiologic evidence for a cardiac benefit for the n-3 fatty acids that appears to contradict the findings of the randomized trials. This chapter will review both trial and prospective cohort study data which, in the aggregate, continues to support the view that n-3 fatty acids are heart healthy.

AB - The long-chain marine n-3 fatty acids have been reported to be cardio protective over many years and many mechanisms of action have been proposed. Up through the first decade of the 21st century, nearly all n-3 randomized trials were positive, but beginning in 2010 several trials were published that did not show a benefit of these fatty acids on clinical cardiovascular endpoints. There is a wealth of epidemiologic evidence for a cardiac benefit for the n-3 fatty acids that appears to contradict the findings of the randomized trials. This chapter will review both trial and prospective cohort study data which, in the aggregate, continues to support the view that n-3 fatty acids are heart healthy.

KW - Cardiovascular disease

KW - Docosahexaenoic acid

KW - Eicosapentaenoic acid

KW - Fish oil

KW - N-3 fatty acids

KW - Prospective cohort studies

KW - Randomized trials

UR - http://www.scopus.com/inward/record.url?scp=85018812555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018812555&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-802844-5.00018-X

DO - 10.1016/B978-0-12-802844-5.00018-X

M3 - Chapter

AN - SCOPUS:85018812555

SN - 9780128028445

SP - 199

EP - 205

BT - Fish and Fish Oil in Health and Disease Prevention

PB - Elsevier Inc.

ER -