Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance

Yongsoon Park, William Harris

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

Omega-3 fatty acids (FAs) reduce postprandial triacylglycerol (TG) concentrations. This study was under-taken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. Healthy subjects (n = 33) began with a 4-week, olive oil placebo (4 g/d) run-in period. After a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (SAF), eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA) for 4 weeks. Results for EPA and DHA were similar, and therefore the data were combined into one ω-3 FA group. Omega-3 FA supplementation reduced the postprandial TG and apolipoprotein B (apo B)-48 and apoB-100 concentrations by 16% (P = 0.08), 28% (P <0.001), and 24% (P <0.01), respectively. Chylomicron TG half-lives in the fed state were reduced after ω-3 FA treatment (6.0 ± 0.5 vs. 5.1 ± 0. 4 min; P <0.05), but not after SAF (6.9 ± 0.7 vs. 7.1 ± 0.7 min). Omega-3 FA supplementation decreased chylomicron particle sizes (mean diameter; 293 ± 44 vs. 175 ± 25 nm; P <0.01) and increased preheparin lipoprotein lipase (LPL; 0.6 ± 0.1 vs. 0.9 ± 0.1 μmol/h/ml; P <0.05) activity during the fed state, but had no effect on postheparin LPL or hepatic lipase activities. The results suggest that ω-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalJournal of Lipid Research
Volume44
Issue number3
DOIs
StatePublished - Mar 2003
Externally publishedYes

Fingerprint

Chylomicrons
Omega-3 Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Triglycerides
Safflower Oil
Fatty Acids
Apolipoprotein B-48
Apolipoprotein B-100
Lipoprotein Lipase
Lipase
Particle Size
Healthy Volunteers
Esters
Particle size
Placebos
Liver
Therapeutics

Keywords

  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Endocrinology

Cite this

Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. / Park, Yongsoon; Harris, William.

In: Journal of Lipid Research, Vol. 44, No. 3, 03.2003, p. 455-463.

Research output: Contribution to journalArticle

Park, Yongsoon ; Harris, William. / Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. In: Journal of Lipid Research. 2003 ; Vol. 44, No. 3. pp. 455-463.
@article{e6735c7437e1467c9d6573ddea776b5c,
title = "Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance",
abstract = "Omega-3 fatty acids (FAs) reduce postprandial triacylglycerol (TG) concentrations. This study was under-taken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. Healthy subjects (n = 33) began with a 4-week, olive oil placebo (4 g/d) run-in period. After a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (SAF), eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA) for 4 weeks. Results for EPA and DHA were similar, and therefore the data were combined into one ω-3 FA group. Omega-3 FA supplementation reduced the postprandial TG and apolipoprotein B (apo B)-48 and apoB-100 concentrations by 16{\%} (P = 0.08), 28{\%} (P <0.001), and 24{\%} (P <0.01), respectively. Chylomicron TG half-lives in the fed state were reduced after ω-3 FA treatment (6.0 ± 0.5 vs. 5.1 ± 0. 4 min; P <0.05), but not after SAF (6.9 ± 0.7 vs. 7.1 ± 0.7 min). Omega-3 FA supplementation decreased chylomicron particle sizes (mean diameter; 293 ± 44 vs. 175 ± 25 nm; P <0.01) and increased preheparin lipoprotein lipase (LPL; 0.6 ± 0.1 vs. 0.9 ± 0.1 μmol/h/ml; P <0.05) activity during the fed state, but had no effect on postheparin LPL or hepatic lipase activities. The results suggest that ω-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective.",
keywords = "Docosahexaenoic acid, Eicosapentaenoic acid, Lipoprotein lipase",
author = "Yongsoon Park and William Harris",
year = "2003",
month = "3",
doi = "10.1194/jlr.M200282-JLR200",
language = "English (US)",
volume = "44",
pages = "455--463",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "3",

}

TY - JOUR

T1 - Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance

AU - Park, Yongsoon

AU - Harris, William

PY - 2003/3

Y1 - 2003/3

N2 - Omega-3 fatty acids (FAs) reduce postprandial triacylglycerol (TG) concentrations. This study was under-taken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. Healthy subjects (n = 33) began with a 4-week, olive oil placebo (4 g/d) run-in period. After a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (SAF), eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA) for 4 weeks. Results for EPA and DHA were similar, and therefore the data were combined into one ω-3 FA group. Omega-3 FA supplementation reduced the postprandial TG and apolipoprotein B (apo B)-48 and apoB-100 concentrations by 16% (P = 0.08), 28% (P <0.001), and 24% (P <0.01), respectively. Chylomicron TG half-lives in the fed state were reduced after ω-3 FA treatment (6.0 ± 0.5 vs. 5.1 ± 0. 4 min; P <0.05), but not after SAF (6.9 ± 0.7 vs. 7.1 ± 0.7 min). Omega-3 FA supplementation decreased chylomicron particle sizes (mean diameter; 293 ± 44 vs. 175 ± 25 nm; P <0.01) and increased preheparin lipoprotein lipase (LPL; 0.6 ± 0.1 vs. 0.9 ± 0.1 μmol/h/ml; P <0.05) activity during the fed state, but had no effect on postheparin LPL or hepatic lipase activities. The results suggest that ω-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective.

AB - Omega-3 fatty acids (FAs) reduce postprandial triacylglycerol (TG) concentrations. This study was under-taken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. Healthy subjects (n = 33) began with a 4-week, olive oil placebo (4 g/d) run-in period. After a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (SAF), eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA) for 4 weeks. Results for EPA and DHA were similar, and therefore the data were combined into one ω-3 FA group. Omega-3 FA supplementation reduced the postprandial TG and apolipoprotein B (apo B)-48 and apoB-100 concentrations by 16% (P = 0.08), 28% (P <0.001), and 24% (P <0.01), respectively. Chylomicron TG half-lives in the fed state were reduced after ω-3 FA treatment (6.0 ± 0.5 vs. 5.1 ± 0. 4 min; P <0.05), but not after SAF (6.9 ± 0.7 vs. 7.1 ± 0.7 min). Omega-3 FA supplementation decreased chylomicron particle sizes (mean diameter; 293 ± 44 vs. 175 ± 25 nm; P <0.01) and increased preheparin lipoprotein lipase (LPL; 0.6 ± 0.1 vs. 0.9 ± 0.1 μmol/h/ml; P <0.05) activity during the fed state, but had no effect on postheparin LPL or hepatic lipase activities. The results suggest that ω-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective.

KW - Docosahexaenoic acid

KW - Eicosapentaenoic acid

KW - Lipoprotein lipase

UR - http://www.scopus.com/inward/record.url?scp=0038281520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038281520&partnerID=8YFLogxK

U2 - 10.1194/jlr.M200282-JLR200

DO - 10.1194/jlr.M200282-JLR200

M3 - Article

C2 - 12562865

AN - SCOPUS:0038281520

VL - 44

SP - 455

EP - 463

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 3

ER -