Ocular toxoplasmosis I: Parasitology, epidemiology and public health

João M. Furtado, Kevin Winthrop, Nicholas J. Butler, Justine R. Smith

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Ocular toxoplasmosis results from retinal infection with the protozoan, Toxoplasma gondii. This parasite, which exists as multiple clonal subpopulations and in three stages, is capable of replication in any nucleated cell of its primary feline or multiple paratenic hosts. Human seroprevalence of toxoplasmosis is high across the globe, but with geographic variation. While prevalence of ocular toxoplasmosis is not well documented, toxoplasmic retinochoroiditis is the commonest form of posterior uveitis in many countries. Correlation of parasite genotype with disease is an important area of new research. Ocular infection with T. gondii often follows ingestion of bradyzoites in undercooked infected meat. Oocysts may survive for an extended period in the environment, and water contaminated with oocysts is an important source in toxoplasmosis epidemics. Ocular toxoplasmosis is preventable by a combination of community activities and personal measures. Public health action is well justified by the considerable burden of congenital and postnatal infections.

Original languageEnglish (US)
Pages (from-to)82-94
Number of pages13
JournalClinical and Experimental Ophthalmology
Volume41
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Ocular Toxoplasmosis
Parasitology
Epidemiology
Oocysts
Public Health
Toxoplasmosis
Toxoplasma
Parasites
Posterior Uveitis
Protozoan Infections
Eye Infections
Felidae
Seroepidemiologic Studies
Meat
Eating
Genotype
Water
Infection
Research

Keywords

  • Epidemiology
  • Public health
  • Toxoplasma gondii
  • Toxoplasmosis
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular toxoplasmosis I : Parasitology, epidemiology and public health. / Furtado, João M.; Winthrop, Kevin; Butler, Nicholas J.; Smith, Justine R.

In: Clinical and Experimental Ophthalmology, Vol. 41, No. 1, 01.2013, p. 82-94.

Research output: Contribution to journalArticle

Furtado, João M. ; Winthrop, Kevin ; Butler, Nicholas J. ; Smith, Justine R. / Ocular toxoplasmosis I : Parasitology, epidemiology and public health. In: Clinical and Experimental Ophthalmology. 2013 ; Vol. 41, No. 1. pp. 82-94.
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