TY - JOUR
T1 - Ocular injury induced by methyl ethyl ketone peroxide
AU - Fraunfelder, F. T.
AU - Coster, D. J.
AU - Drew, R.
AU - Fraunfelder, Frederick (Rick)
N1 - Funding Information:
Accepted for publication Aug. 20, 1990. From the Department of Ophthalmology, Oregon Health Sciences University, Portland, Oregon (Dr. Fraunfelder and Mr. Fraunfelder); and Departments of Ophthalmology (Dr. Coster) and Clinical Pharmacology (Dr. Drew), Flinders Medical Center, Adelaide, South Australia. This study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc. Reprint requests to F. T. Fraunfelder, M.D., Department of Ophthalmology, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201-3098.
PY - 1990
Y1 - 1990
N2 - Methyl ethyl ketone peroxide is a commonly used catalyst in various industries. We studied 19 eyes with a single exposure to methyl ethyl ketone peroxide that developed clinical patterns of mild injury, moderate injury, severe injury, or delayed keratitis. Delayed methyl ethyl ketone peroxide keratitis may cause exacerbations and remissions of corneal and limbal disease lasting more than 20 years with palpebral and bulbar hyperemia equal to the initial chemical exposure. With repeat exacerbation, further pannus may occur, which can be associated with a poorer outcome. Based on the capability of methyl ethyl ketone peroxide to change DNA to a new weak antigen, we suggest possible methods of therapy to prevent or limit delayed methyl ethyl ketone peroxide keratitis. This proposed type of injury has important implications in studying various limbal and corneal diseases. A major factor in the severity of ocular injury was the length of time from exposure to methyl ethyl ketone peroxide to obtaining a topical ocular local anesthetic to perform adequate lavage.
AB - Methyl ethyl ketone peroxide is a commonly used catalyst in various industries. We studied 19 eyes with a single exposure to methyl ethyl ketone peroxide that developed clinical patterns of mild injury, moderate injury, severe injury, or delayed keratitis. Delayed methyl ethyl ketone peroxide keratitis may cause exacerbations and remissions of corneal and limbal disease lasting more than 20 years with palpebral and bulbar hyperemia equal to the initial chemical exposure. With repeat exacerbation, further pannus may occur, which can be associated with a poorer outcome. Based on the capability of methyl ethyl ketone peroxide to change DNA to a new weak antigen, we suggest possible methods of therapy to prevent or limit delayed methyl ethyl ketone peroxide keratitis. This proposed type of injury has important implications in studying various limbal and corneal diseases. A major factor in the severity of ocular injury was the length of time from exposure to methyl ethyl ketone peroxide to obtaining a topical ocular local anesthetic to perform adequate lavage.
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U2 - 10.1016/S0002-9394(14)77060-6
DO - 10.1016/S0002-9394(14)77060-6
M3 - Article
C2 - 2248327
AN - SCOPUS:0025649362
VL - 110
SP - 635
EP - 640
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 6
ER -