Ocular Complications of Vincristine Therapy

Daniel Albert, Vernon G. Wong, Edward S. Henderson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Vincristine sulfate (Oncovin) is a commonly used drug in the treatment of acute leukemia and other malignancies. This paper lists a series of 20 patients with ptosis, other ocular muscle paresis, and fifth and seventh nerve involvement which appeared to have been induced by vincristine. Most showed signs of peripheral neuropathy, other cranial nerve palsies, nausea and vomiting, constipation, or alopecia as well. Toxic reactions usually improved following decreased dosage or discontinuation of drug therapy.

Original languageEnglish (US)
Pages (from-to)709-713
Number of pages5
JournalArchives of ophthalmology
Volume78
Issue number6
DOIs
StatePublished - Jan 1 1967
Externally publishedYes

Fingerprint

Vincristine
Cranial Nerve Diseases
Poisons
Alopecia
Peripheral Nervous System Diseases
Paresis
Constipation
Nausea
Vomiting
Leukemia
Therapeutics
Drug Therapy
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular Complications of Vincristine Therapy. / Albert, Daniel; Wong, Vernon G.; Henderson, Edward S.

In: Archives of ophthalmology, Vol. 78, No. 6, 01.01.1967, p. 709-713.

Research output: Contribution to journalArticle

Albert, Daniel ; Wong, Vernon G. ; Henderson, Edward S. / Ocular Complications of Vincristine Therapy. In: Archives of ophthalmology. 1967 ; Vol. 78, No. 6. pp. 709-713.
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