Ocular clinical findings and basement membrane changes in Goodpasture's syndrome

Lee M. Jampol, Moshe Lahav, Daniel Albert, Joseph Craft

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Goodpasture's syndrome is a rapidly progressive disease characterized by the onset of pulmonary hemorrhage with glomerulonephritis, leading to pulmonary and renal failure. The hallmark of this disease is linear deposition of antibasement membrane IgG in the basement membranes of the kidney and lung. In two cases of nonrhegmatogenous retinal detachment in patients with Goodpasture's syndrome, the first patient demonstrated multiple ischemic areas in the choroid on fluorescein angiography. Histopathologic and immunologic studies of the eyes of the second patient demonstrated macular edema and elevation of the retina in association with choroidal infarction and linear deposition of IgG in Bruch's membrane and the basement membranes of the choroidal vessels.

Original languageEnglish (US)
Pages (from-to)452-455
Number of pages4
JournalAmerican Journal of Ophthalmology
Volume79
Issue number3
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

Anti-Glomerular Basement Membrane Disease
Basement Membrane
Immunoglobulin G
Bruch Membrane
Lung
Macular Edema
Choroid
Fluorescein Angiography
Retinal Detachment
Infarction
Renal Insufficiency
Retina
Kidney
Membranes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular clinical findings and basement membrane changes in Goodpasture's syndrome. / Jampol, Lee M.; Lahav, Moshe; Albert, Daniel; Craft, Joseph.

In: American Journal of Ophthalmology, Vol. 79, No. 3, 01.01.1975, p. 452-455.

Research output: Contribution to journalArticle

Jampol, Lee M. ; Lahav, Moshe ; Albert, Daniel ; Craft, Joseph. / Ocular clinical findings and basement membrane changes in Goodpasture's syndrome. In: American Journal of Ophthalmology. 1975 ; Vol. 79, No. 3. pp. 452-455.
@article{6acde1f7e4ae49e9b46e16314afa5bee,
title = "Ocular clinical findings and basement membrane changes in Goodpasture's syndrome",
abstract = "Goodpasture's syndrome is a rapidly progressive disease characterized by the onset of pulmonary hemorrhage with glomerulonephritis, leading to pulmonary and renal failure. The hallmark of this disease is linear deposition of antibasement membrane IgG in the basement membranes of the kidney and lung. In two cases of nonrhegmatogenous retinal detachment in patients with Goodpasture's syndrome, the first patient demonstrated multiple ischemic areas in the choroid on fluorescein angiography. Histopathologic and immunologic studies of the eyes of the second patient demonstrated macular edema and elevation of the retina in association with choroidal infarction and linear deposition of IgG in Bruch's membrane and the basement membranes of the choroidal vessels.",
author = "Jampol, {Lee M.} and Moshe Lahav and Daniel Albert and Joseph Craft",
year = "1975",
month = "1",
day = "1",
doi = "10.1016/0002-9394(75)90622-4",
language = "English (US)",
volume = "79",
pages = "452--455",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Ocular clinical findings and basement membrane changes in Goodpasture's syndrome

AU - Jampol, Lee M.

AU - Lahav, Moshe

AU - Albert, Daniel

AU - Craft, Joseph

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Goodpasture's syndrome is a rapidly progressive disease characterized by the onset of pulmonary hemorrhage with glomerulonephritis, leading to pulmonary and renal failure. The hallmark of this disease is linear deposition of antibasement membrane IgG in the basement membranes of the kidney and lung. In two cases of nonrhegmatogenous retinal detachment in patients with Goodpasture's syndrome, the first patient demonstrated multiple ischemic areas in the choroid on fluorescein angiography. Histopathologic and immunologic studies of the eyes of the second patient demonstrated macular edema and elevation of the retina in association with choroidal infarction and linear deposition of IgG in Bruch's membrane and the basement membranes of the choroidal vessels.

AB - Goodpasture's syndrome is a rapidly progressive disease characterized by the onset of pulmonary hemorrhage with glomerulonephritis, leading to pulmonary and renal failure. The hallmark of this disease is linear deposition of antibasement membrane IgG in the basement membranes of the kidney and lung. In two cases of nonrhegmatogenous retinal detachment in patients with Goodpasture's syndrome, the first patient demonstrated multiple ischemic areas in the choroid on fluorescein angiography. Histopathologic and immunologic studies of the eyes of the second patient demonstrated macular edema and elevation of the retina in association with choroidal infarction and linear deposition of IgG in Bruch's membrane and the basement membranes of the choroidal vessels.

UR - http://www.scopus.com/inward/record.url?scp=0016740524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016740524&partnerID=8YFLogxK

U2 - 10.1016/0002-9394(75)90622-4

DO - 10.1016/0002-9394(75)90622-4

M3 - Article

VL - 79

SP - 452

EP - 455

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -