Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma

M. A. Chang, G. Fournier, H. K. Koh, A. J. Sober, H. Nakagawa, T. B. Fitzpatrick, Daniel Albert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the Massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume224
Issue number6
DOIs
StatePublished - Nov 1 1986
Externally publishedYes

Fingerprint

Eye Abnormalities
Hypopigmentation
Melanoma
Skin
Choroid
Halo Nevi
Vitiligo
Eye Diseases
Retinal Pigment Epithelium
General Hospitals
Atrophy
Pathology
Inflammation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma. / Chang, M. A.; Fournier, G.; Koh, H. K.; Sober, A. J.; Nakagawa, H.; Fitzpatrick, T. B.; Albert, Daniel.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 224, No. 6, 01.11.1986, p. 529-535.

Research output: Contribution to journalArticle

Chang, M. A. ; Fournier, G. ; Koh, H. K. ; Sober, A. J. ; Nakagawa, H. ; Fitzpatrick, T. B. ; Albert, Daniel. / Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 1986 ; Vol. 224, No. 6. pp. 529-535.
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