Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy

Grazyna Adamus, Rachel Champaigne, Sufang Yang

Research output: Contribution to journalArticle

Abstract

Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

Original languageEnglish (US)
Article number108317
JournalClinical Immunology
Volume210
DOIs
StatePublished - Jan 2020

Fingerprint

Ocular Paraneoplastic Syndromes
Autoantibodies
Biomarkers
Arrestin
Paraneoplastic Syndromes
Antigens
Retinal Diseases
Neoplasms
Fructose-Bisphosphate Aldolase
Phosphopyruvate Hydratase
Colonic Neoplasms
Melanoma
Prostatic Neoplasms
Neoplasm Metastasis
Skin
Incidence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy. / Adamus, Grazyna; Champaigne, Rachel; Yang, Sufang.

In: Clinical Immunology, Vol. 210, 108317, 01.2020.

Research output: Contribution to journalArticle

@article{ef4b9d32ecef43999205bdb2d998a357,
title = "Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy",
abstract = "Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.",
author = "Grazyna Adamus and Rachel Champaigne and Sufang Yang",
year = "2020",
month = "1",
doi = "10.1016/j.clim.2019.108317",
language = "English (US)",
volume = "210",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy

AU - Adamus, Grazyna

AU - Champaigne, Rachel

AU - Yang, Sufang

PY - 2020/1

Y1 - 2020/1

N2 - Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

AB - Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

UR - http://www.scopus.com/inward/record.url?scp=85075870901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075870901&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2019.108317

DO - 10.1016/j.clim.2019.108317

M3 - Article

C2 - 31770612

AN - SCOPUS:85075870901

VL - 210

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

M1 - 108317

ER -