Obesity is associated with copper elevation in serum and tissues

Haojun Yang, Chin Nung Liu, Risa M. Wolf, Martina Ralle, Som Dev, Hannah Pierson, Frederic Askin, Kimberley E. Steele, Thomas H. Magnuson, Michael A. Schweitzer, G. William Wong, Svetlana Lutsenko

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Copper misbalance has been linked to fat accumulation in animals and experimental systems; however, information about copper homeostasis in human obesity is limited. In this study, the copper status of obese individuals was evaluated by measuring their levels of copper and cuproproteins in serum, adipose and hepatic tissues. The analysis of serum trace elements showed significant positive and element-specific correlation between copper and BMI after controlling for gender, age, and ethnicity. Serum copper also positively correlated with leptin, insulin, and the leptin/BMI ratio. When compared to lean controls, obese patients had elevated circulating cuproproteins, such as semucarbazide-sensitive amine oxidase (SSAO) and ceruloplasmin, and higher SSAO activity and copper levels in visceral fat. Although hepatic steatosis reduces copper levels in the liver, obese patients with no or mild steatosis have higher copper content in the liver compared to lean controls. In conclusion, obese patients evaluated in this study had altered copper status. Strong positive correlations of copper levels with BMI and leptin suggest that copper and/or cuproproteins may be functionally linked to fat accumulation.

Original languageEnglish (US)
Pages (from-to)1363-1371
Number of pages9
JournalMetallomics
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Copper
Obesity
Tissue
Serum
Leptin
Oils and fats
Liver
Fats
Amines
Amine Oxidase (Copper-Containing)
Intra-Abdominal Fat
Trace Elements
Insulin
Trace elements
Chemical elements
Adipose Tissue
Homeostasis
Oxidoreductases
Animals

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biophysics
  • Biomaterials
  • Biochemistry
  • Metals and Alloys

Cite this

Yang, H., Liu, C. N., Wolf, R. M., Ralle, M., Dev, S., Pierson, H., ... Lutsenko, S. (2019). Obesity is associated with copper elevation in serum and tissues. Metallomics, 11(8), 1363-1371. https://doi.org/10.1039/c9mt00148d

Obesity is associated with copper elevation in serum and tissues. / Yang, Haojun; Liu, Chin Nung; Wolf, Risa M.; Ralle, Martina; Dev, Som; Pierson, Hannah; Askin, Frederic; Steele, Kimberley E.; Magnuson, Thomas H.; Schweitzer, Michael A.; Wong, G. William; Lutsenko, Svetlana.

In: Metallomics, Vol. 11, No. 8, 01.08.2019, p. 1363-1371.

Research output: Contribution to journalArticle

Yang, H, Liu, CN, Wolf, RM, Ralle, M, Dev, S, Pierson, H, Askin, F, Steele, KE, Magnuson, TH, Schweitzer, MA, Wong, GW & Lutsenko, S 2019, 'Obesity is associated with copper elevation in serum and tissues', Metallomics, vol. 11, no. 8, pp. 1363-1371. https://doi.org/10.1039/c9mt00148d
Yang H, Liu CN, Wolf RM, Ralle M, Dev S, Pierson H et al. Obesity is associated with copper elevation in serum and tissues. Metallomics. 2019 Aug 1;11(8):1363-1371. https://doi.org/10.1039/c9mt00148d
Yang, Haojun ; Liu, Chin Nung ; Wolf, Risa M. ; Ralle, Martina ; Dev, Som ; Pierson, Hannah ; Askin, Frederic ; Steele, Kimberley E. ; Magnuson, Thomas H. ; Schweitzer, Michael A. ; Wong, G. William ; Lutsenko, Svetlana. / Obesity is associated with copper elevation in serum and tissues. In: Metallomics. 2019 ; Vol. 11, No. 8. pp. 1363-1371.
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