TY - JOUR
T1 - Nutrition for the ageing brain
T2 - Towards evidence for an optimal diet
AU - Vauzour, David
AU - Camprubi-Robles, Maria
AU - Miquel-Kergoat, Sophie
AU - Andres-Lacueva, Cristina
AU - Bánáti, Diána
AU - Barberger-Gateau, Pascale
AU - Bowman, Gene L.
AU - Caberlotto, Laura
AU - Clarke, Robert
AU - Hogervorst, Eef
AU - Kiliaan, Amanda J.
AU - Lucca, Ugo
AU - Manach, Claudine
AU - Minihane, Anne Marie
AU - Mitchell, Ellen Siobhan
AU - Perneczky, Robert
AU - Perry, Hugh
AU - Roussel, Anne Marie
AU - Schuermans, Jeroen
AU - Sijben, John
AU - Spencer, Jeremy P.E.
AU - Thuret, Sandrine
AU - van de Rest, Ondine
AU - Vandewoude, Maurits
AU - Wesnes, Keith
AU - Williams, Robert J.
AU - Williams, Robin S.B.
AU - Ramirez, Maria
N1 - Publisher Copyright:
© 2016 The Authors
PY - 2017/5/1
Y1 - 2017/5/1
N2 - As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.
AB - As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.
KW - Cognition
KW - Cognitive ageing
KW - Cognitive decline
KW - Neuroinflammation
KW - Neuroprotection
KW - Preventive diet
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U2 - 10.1016/j.arr.2016.09.010
DO - 10.1016/j.arr.2016.09.010
M3 - Review article
C2 - 27713095
AN - SCOPUS:85008643963
SN - 1568-1637
VL - 35
SP - 222
EP - 240
JO - Ageing Research Reviews
JF - Ageing Research Reviews
ER -