Nutrition for the ageing brain: Towards evidence for an optimal diet

David Vauzour, Maria Camprubi-Robles, Sophie Miquel-Kergoat, Cristina Andres-Lacueva, Diána Bánáti, Pascale Barberger-Gateau, Gene Bowman, Laura Caberlotto, Robert Clarke, Eef Hogervorst, Amanda J. Kiliaan, Ugo Lucca, Claudine Manach, Anne Marie Minihane, Ellen Siobhan Mitchell, Robert Perneczky, Hugh Perry, Anne Marie Roussel, Jeroen Schuermans, John SijbenJeremy P.E. Spencer, Sandrine Thuret, Ondine van de Rest, Maurits Vandewoude, Keith Wesnes, Robert J. Williams, Robin S.B. Williams, Maria Ramirez

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.

Original languageEnglish (US)
Pages (from-to)222-240
Number of pages19
JournalAgeing Research Reviews
Volume35
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Nutrition
Brain
Aging of materials
Diet
Research
Biological Science Disciplines
Brain Diseases
Advisory Committees
Cognition
Biomarkers
Nutrients
Maintenance
Food
Population
Cognitive Dysfunction

Keywords

  • Cognition
  • Cognitive ageing
  • Cognitive decline
  • Neuroinflammation
  • Neuroprotection
  • Preventive diet

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., ... Ramirez, M. (2017). Nutrition for the ageing brain: Towards evidence for an optimal diet. Ageing Research Reviews, 35, 222-240. https://doi.org/10.1016/j.arr.2016.09.010

Nutrition for the ageing brain : Towards evidence for an optimal diet. / Vauzour, David; Camprubi-Robles, Maria; Miquel-Kergoat, Sophie; Andres-Lacueva, Cristina; Bánáti, Diána; Barberger-Gateau, Pascale; Bowman, Gene; Caberlotto, Laura; Clarke, Robert; Hogervorst, Eef; Kiliaan, Amanda J.; Lucca, Ugo; Manach, Claudine; Minihane, Anne Marie; Mitchell, Ellen Siobhan; Perneczky, Robert; Perry, Hugh; Roussel, Anne Marie; Schuermans, Jeroen; Sijben, John; Spencer, Jeremy P.E.; Thuret, Sandrine; van de Rest, Ondine; Vandewoude, Maurits; Wesnes, Keith; Williams, Robert J.; Williams, Robin S.B.; Ramirez, Maria.

In: Ageing Research Reviews, Vol. 35, 01.05.2017, p. 222-240.

Research output: Contribution to journalReview article

Vauzour, D, Camprubi-Robles, M, Miquel-Kergoat, S, Andres-Lacueva, C, Bánáti, D, Barberger-Gateau, P, Bowman, G, Caberlotto, L, Clarke, R, Hogervorst, E, Kiliaan, AJ, Lucca, U, Manach, C, Minihane, AM, Mitchell, ES, Perneczky, R, Perry, H, Roussel, AM, Schuermans, J, Sijben, J, Spencer, JPE, Thuret, S, van de Rest, O, Vandewoude, M, Wesnes, K, Williams, RJ, Williams, RSB & Ramirez, M 2017, 'Nutrition for the ageing brain: Towards evidence for an optimal diet', Ageing Research Reviews, vol. 35, pp. 222-240. https://doi.org/10.1016/j.arr.2016.09.010
Vauzour D, Camprubi-Robles M, Miquel-Kergoat S, Andres-Lacueva C, Bánáti D, Barberger-Gateau P et al. Nutrition for the ageing brain: Towards evidence for an optimal diet. Ageing Research Reviews. 2017 May 1;35:222-240. https://doi.org/10.1016/j.arr.2016.09.010
Vauzour, David ; Camprubi-Robles, Maria ; Miquel-Kergoat, Sophie ; Andres-Lacueva, Cristina ; Bánáti, Diána ; Barberger-Gateau, Pascale ; Bowman, Gene ; Caberlotto, Laura ; Clarke, Robert ; Hogervorst, Eef ; Kiliaan, Amanda J. ; Lucca, Ugo ; Manach, Claudine ; Minihane, Anne Marie ; Mitchell, Ellen Siobhan ; Perneczky, Robert ; Perry, Hugh ; Roussel, Anne Marie ; Schuermans, Jeroen ; Sijben, John ; Spencer, Jeremy P.E. ; Thuret, Sandrine ; van de Rest, Ondine ; Vandewoude, Maurits ; Wesnes, Keith ; Williams, Robert J. ; Williams, Robin S.B. ; Ramirez, Maria. / Nutrition for the ageing brain : Towards evidence for an optimal diet. In: Ageing Research Reviews. 2017 ; Vol. 35. pp. 222-240.
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