Nucleoside transporters of parasitic protozoa

Nicola Carter, Scott Landfear, Buddy Ullman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Protozoan parasites are incapable of synthesizing purine nucleotides de novo and so must salvage preformed purines from their hosts. This process of purine acquisition is initiated by the translocation of preformed host purines across parasite or host membranes. Here, we report upon the identification and isolation of DNAs encoding parasite nucleoside transporters and the functional characterization of these proteins in various expression systems. These potential approaches provide a powerful approach for a thorough molecular and biochemical dissection of nucleoside transport in protozoan parasites.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalTrends in Parasitology
Volume17
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Nucleoside Transport Proteins
Parasites
Purines
Purine Nucleotides
Nucleosides
Dissection
Membranes
DNA
Proteins

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Nucleoside transporters of parasitic protozoa. / Carter, Nicola; Landfear, Scott; Ullman, Buddy.

In: Trends in Parasitology, Vol. 17, No. 3, 2001, p. 142-145.

Research output: Contribution to journalArticle

Carter, Nicola ; Landfear, Scott ; Ullman, Buddy. / Nucleoside transporters of parasitic protozoa. In: Trends in Parasitology. 2001 ; Vol. 17, No. 3. pp. 142-145.
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