Novel approaches to whole sporozoite vaccination against malaria

Else M. Bijker, Steffen Borrmann, Stefan H. Kappe, Benjamin Mordmüller, Brandon K. Sack, Shahid M. Khan

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The parasitic disease malaria threatens more than 3 billion people worldwide, resulting in more than 200 million clinical cases and almost 600,000 deaths annually. Vaccines remain crucial for prevention and ultimately eradication of infectious diseases and, for malaria, whole sporozoite based immunization has been shown to be the most effective in experimental settings. In addition to immunization with radiation-attenuated sporozoites, chemoprophylaxis and sporozoites (CPS) is a highly efficient strategy to induce sterile protection in humans. Genetically attenuated parasites (GAP) have demonstrated significant protection in rodent studies, and are now being advanced into clinical testing. This review describes the existing pre-clinical and clinical data on CPS and GAP, discusses recent developments and examines how to transform these immunization approaches into vaccine candidates for clinical development.

Original languageEnglish (US)
Pages (from-to)7462-7468
Number of pages7
Issue number52
StatePublished - Dec 22 2015
Externally publishedYes


  • Chemoprophylaxis
  • Chloroquine
  • Genetic attenuation
  • Immunization
  • Liver stage
  • Malaria
  • Plasmodium
  • Pre-erythrocytic stages
  • Sporozoite
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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