North American Contact Dermatitis Group standard tray patch test results (1992 to 1994)

James G. Marks, Donald V. Belsito, Vincent A. DeLeo, Joseph F. Fowler, Anthony F. Fransway, Howard I. Maibach, C. G Toby Mathias, James R. Nethercott, Robert L. Rietschel, Lawrence E. Rosenthal, Elizabeth F. Sherertz, Frances Storrs, James S. Taylor

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: Allergic contact dermatitis is a significant cause of cutaneous disease for which patch testing often provides diagnostic support. Objective: This paper reports, as a follow-up of our previous studies, the results of patch testing from July 1, 1992, to June 30, 1994, by the North American Contact Dermatitis Group. Methods: Patients evaluated in the patch test clinics of the North American Contact Dermatitis Group were tested to the same screening tray of allergens using a standardized patch testing technique. The data from these patients were recorded on a standard computer entry form and analyzed. Results: Fifty-two allergens were tested during a 2-year period on 3,549 patients. Sixty-five percent of patients had positive patch test reactions. Fifty-two percent of the patients had reactions believed to be clinically relevant to the present or past dermatitis. The 20 standard screening allergens commercially available in the United States accounted for only 50% of the patients with positive allergic reactions. The 12 most frequent contact allergens were nickel sulfate, fragrance mix, thimerosal, quaternium-15, neomycin sulfate, formaldehyde, bacitracin, thiuram mix, balsam of Peru, cobalt chloride, p-phenylenediamine, and carba mix. The present and past relevance varied with the specific allergen from 45% (thimerosal) to 84% (thiuram mix). Among some newer allergens, methyldibromoglutaronitrile/phenoxyethanol (cosmetic preservative) caused positive reactions in 1.5% of the patients, and tixocortol-21-pivalate (corticosteroid) was positive in 2.5%. Conclusion: Patch testing remains a worthwhile diagnostic tool in the evaluation of patients with suspected allergic contact dermatitis. The usefulness of this technique is enhanced with the number of allergens tested. The information from this investigation will aid further development of a standard series for North America.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalAmerican Journal of Contact Dermatitis
Volume6
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Patch Tests
Contact Dermatitis
Allergens
Thiram
Thimerosal
Allergic Contact Dermatitis
Bacitracin
Neomycin
Dermatitis
North America
Skin Diseases
Cosmetics
Formaldehyde
Adrenal Cortex Hormones
Hypersensitivity

ASJC Scopus subject areas

  • Dermatology

Cite this

Marks, J. G., Belsito, D. V., DeLeo, V. A., Fowler, J. F., Fransway, A. F., Maibach, H. I., ... Taylor, J. S. (1995). North American Contact Dermatitis Group standard tray patch test results (1992 to 1994). American Journal of Contact Dermatitis, 6(3), 160-165. https://doi.org/10.1016/1046-199X(95)90122-1

North American Contact Dermatitis Group standard tray patch test results (1992 to 1994). / Marks, James G.; Belsito, Donald V.; DeLeo, Vincent A.; Fowler, Joseph F.; Fransway, Anthony F.; Maibach, Howard I.; Mathias, C. G Toby; Nethercott, James R.; Rietschel, Robert L.; Rosenthal, Lawrence E.; Sherertz, Elizabeth F.; Storrs, Frances; Taylor, James S.

In: American Journal of Contact Dermatitis, Vol. 6, No. 3, 1995, p. 160-165.

Research output: Contribution to journalArticle

Marks, JG, Belsito, DV, DeLeo, VA, Fowler, JF, Fransway, AF, Maibach, HI, Mathias, CGT, Nethercott, JR, Rietschel, RL, Rosenthal, LE, Sherertz, EF, Storrs, F & Taylor, JS 1995, 'North American Contact Dermatitis Group standard tray patch test results (1992 to 1994)', American Journal of Contact Dermatitis, vol. 6, no. 3, pp. 160-165. https://doi.org/10.1016/1046-199X(95)90122-1
Marks, James G. ; Belsito, Donald V. ; DeLeo, Vincent A. ; Fowler, Joseph F. ; Fransway, Anthony F. ; Maibach, Howard I. ; Mathias, C. G Toby ; Nethercott, James R. ; Rietschel, Robert L. ; Rosenthal, Lawrence E. ; Sherertz, Elizabeth F. ; Storrs, Frances ; Taylor, James S. / North American Contact Dermatitis Group standard tray patch test results (1992 to 1994). In: American Journal of Contact Dermatitis. 1995 ; Vol. 6, No. 3. pp. 160-165.
@article{382ab5d25f6740b9b16c8e108710be79,
title = "North American Contact Dermatitis Group standard tray patch test results (1992 to 1994)",
abstract = "Background: Allergic contact dermatitis is a significant cause of cutaneous disease for which patch testing often provides diagnostic support. Objective: This paper reports, as a follow-up of our previous studies, the results of patch testing from July 1, 1992, to June 30, 1994, by the North American Contact Dermatitis Group. Methods: Patients evaluated in the patch test clinics of the North American Contact Dermatitis Group were tested to the same screening tray of allergens using a standardized patch testing technique. The data from these patients were recorded on a standard computer entry form and analyzed. Results: Fifty-two allergens were tested during a 2-year period on 3,549 patients. Sixty-five percent of patients had positive patch test reactions. Fifty-two percent of the patients had reactions believed to be clinically relevant to the present or past dermatitis. The 20 standard screening allergens commercially available in the United States accounted for only 50{\%} of the patients with positive allergic reactions. The 12 most frequent contact allergens were nickel sulfate, fragrance mix, thimerosal, quaternium-15, neomycin sulfate, formaldehyde, bacitracin, thiuram mix, balsam of Peru, cobalt chloride, p-phenylenediamine, and carba mix. The present and past relevance varied with the specific allergen from 45{\%} (thimerosal) to 84{\%} (thiuram mix). Among some newer allergens, methyldibromoglutaronitrile/phenoxyethanol (cosmetic preservative) caused positive reactions in 1.5{\%} of the patients, and tixocortol-21-pivalate (corticosteroid) was positive in 2.5{\%}. Conclusion: Patch testing remains a worthwhile diagnostic tool in the evaluation of patients with suspected allergic contact dermatitis. The usefulness of this technique is enhanced with the number of allergens tested. The information from this investigation will aid further development of a standard series for North America.",
author = "Marks, {James G.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Fowler, {Joseph F.} and Fransway, {Anthony F.} and Maibach, {Howard I.} and Mathias, {C. G Toby} and Nethercott, {James R.} and Rietschel, {Robert L.} and Rosenthal, {Lawrence E.} and Sherertz, {Elizabeth F.} and Frances Storrs and Taylor, {James S.}",
year = "1995",
doi = "10.1016/1046-199X(95)90122-1",
language = "English (US)",
volume = "6",
pages = "160--165",
journal = "Dermatitis : contact, atopic, occupational, drug",
issn = "1710-3568",
publisher = "Decker Publishing",
number = "3",

}

TY - JOUR

T1 - North American Contact Dermatitis Group standard tray patch test results (1992 to 1994)

AU - Marks, James G.

AU - Belsito, Donald V.

AU - DeLeo, Vincent A.

AU - Fowler, Joseph F.

AU - Fransway, Anthony F.

AU - Maibach, Howard I.

AU - Mathias, C. G Toby

AU - Nethercott, James R.

AU - Rietschel, Robert L.

AU - Rosenthal, Lawrence E.

AU - Sherertz, Elizabeth F.

AU - Storrs, Frances

AU - Taylor, James S.

PY - 1995

Y1 - 1995

N2 - Background: Allergic contact dermatitis is a significant cause of cutaneous disease for which patch testing often provides diagnostic support. Objective: This paper reports, as a follow-up of our previous studies, the results of patch testing from July 1, 1992, to June 30, 1994, by the North American Contact Dermatitis Group. Methods: Patients evaluated in the patch test clinics of the North American Contact Dermatitis Group were tested to the same screening tray of allergens using a standardized patch testing technique. The data from these patients were recorded on a standard computer entry form and analyzed. Results: Fifty-two allergens were tested during a 2-year period on 3,549 patients. Sixty-five percent of patients had positive patch test reactions. Fifty-two percent of the patients had reactions believed to be clinically relevant to the present or past dermatitis. The 20 standard screening allergens commercially available in the United States accounted for only 50% of the patients with positive allergic reactions. The 12 most frequent contact allergens were nickel sulfate, fragrance mix, thimerosal, quaternium-15, neomycin sulfate, formaldehyde, bacitracin, thiuram mix, balsam of Peru, cobalt chloride, p-phenylenediamine, and carba mix. The present and past relevance varied with the specific allergen from 45% (thimerosal) to 84% (thiuram mix). Among some newer allergens, methyldibromoglutaronitrile/phenoxyethanol (cosmetic preservative) caused positive reactions in 1.5% of the patients, and tixocortol-21-pivalate (corticosteroid) was positive in 2.5%. Conclusion: Patch testing remains a worthwhile diagnostic tool in the evaluation of patients with suspected allergic contact dermatitis. The usefulness of this technique is enhanced with the number of allergens tested. The information from this investigation will aid further development of a standard series for North America.

AB - Background: Allergic contact dermatitis is a significant cause of cutaneous disease for which patch testing often provides diagnostic support. Objective: This paper reports, as a follow-up of our previous studies, the results of patch testing from July 1, 1992, to June 30, 1994, by the North American Contact Dermatitis Group. Methods: Patients evaluated in the patch test clinics of the North American Contact Dermatitis Group were tested to the same screening tray of allergens using a standardized patch testing technique. The data from these patients were recorded on a standard computer entry form and analyzed. Results: Fifty-two allergens were tested during a 2-year period on 3,549 patients. Sixty-five percent of patients had positive patch test reactions. Fifty-two percent of the patients had reactions believed to be clinically relevant to the present or past dermatitis. The 20 standard screening allergens commercially available in the United States accounted for only 50% of the patients with positive allergic reactions. The 12 most frequent contact allergens were nickel sulfate, fragrance mix, thimerosal, quaternium-15, neomycin sulfate, formaldehyde, bacitracin, thiuram mix, balsam of Peru, cobalt chloride, p-phenylenediamine, and carba mix. The present and past relevance varied with the specific allergen from 45% (thimerosal) to 84% (thiuram mix). Among some newer allergens, methyldibromoglutaronitrile/phenoxyethanol (cosmetic preservative) caused positive reactions in 1.5% of the patients, and tixocortol-21-pivalate (corticosteroid) was positive in 2.5%. Conclusion: Patch testing remains a worthwhile diagnostic tool in the evaluation of patients with suspected allergic contact dermatitis. The usefulness of this technique is enhanced with the number of allergens tested. The information from this investigation will aid further development of a standard series for North America.

UR - http://www.scopus.com/inward/record.url?scp=0029081860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029081860&partnerID=8YFLogxK

U2 - 10.1016/1046-199X(95)90122-1

DO - 10.1016/1046-199X(95)90122-1

M3 - Article

AN - SCOPUS:0029081860

VL - 6

SP - 160

EP - 165

JO - Dermatitis : contact, atopic, occupational, drug

JF - Dermatitis : contact, atopic, occupational, drug

SN - 1710-3568

IS - 3

ER -