Nontuberculous mycobacteria infections in immunosuppressed hosts

Emily Henkle, Kevin Winthrop

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Extrapulmonary NTM disease, including disseminated, skin, and catheter-related disease, is more common in immunosuppressed than immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection, but rapid growers including Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum play an important role in skin and catheter-related infections. With the exception of antibiotic prophylaxis for AIDS patients, the prevention of NTM remains difficult. Management is complicated, involving restoration of immune function and removal of catheters in addition to treatment with species-specific antibiotics per current guidelines.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalClinics in Chest Medicine
Volume36
Issue number1
DOIs
StatePublished - Mar 1 2015

Fingerprint

Nontuberculous Mycobacterium Infections
Immunocompromised Host
Catheters
Mycobacterium chelonae
Mycobacterium fortuitum
Catheter-Related Infections
Mycobacterium avium Complex
Skin
Antibiotic Prophylaxis
Mycobacterium
Cellular Immunity
Acquired Immunodeficiency Syndrome
Guidelines
Anti-Bacterial Agents
Therapeutics
Infection

Keywords

  • Extrapulmonary nontuberculous mycobacteria
  • Immunosuppressive therapy
  • Mycobacterium avium
  • Transplant

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Nontuberculous mycobacteria infections in immunosuppressed hosts. / Henkle, Emily; Winthrop, Kevin.

In: Clinics in Chest Medicine, Vol. 36, No. 1, 01.03.2015, p. 91-99.

Research output: Contribution to journalArticle

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