Noninvasive in vivo optical characterization of blood flow and oxygen consumption in the superficial plexus of skin

Faezeh Talebi Liasi, Ravikant Samatham, Steven Jacques

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Assessing the metabolic activity of a tissue, whether normal, damaged, aged, or pathologic, is useful for diagnosis and evaluating the effects of drugs. This report describes a handheld optical fiber probe that contacts the skin, applies pressure to blanch the superficial vascular plexus of the skin, then releases the pressure to allow refill of the plexus. The optical probe uses white light spectroscopy to record the time dynamics of blanching and refilling. The magnitude and dynamics of changes in blood content and hemoglobin oxygen saturation yield an estimate of the oxygen consumption rate (OCR) in units of attomoles per cell per second. The average value of OCR on nine forearm sites on five subjects was 10±5 (amol/cell/s). This low-cost, portable, rapid, noninvasive optical probe can characterize the OCR of a skin site to assess the metabolic activity of the epidermis or a superficial lesion.

Original languageEnglish (US)
Article number115002
JournalJournal of Biomedical Optics
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

oxygen consumption
blood flow
Skin
Blood
Oxygen
probes
Hemoglobin oxygen saturation
Blanching
refilling
forearm
epidermis
hemoglobin
cells
lesions
blood
Optical fibers
drugs
optical fibers
Spectroscopy
Tissue

Keywords

  • epidermis
  • optical fibers
  • oxygen consumption
  • skin
  • spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Noninvasive in vivo optical characterization of blood flow and oxygen consumption in the superficial plexus of skin. / Liasi, Faezeh Talebi; Samatham, Ravikant; Jacques, Steven.

In: Journal of Biomedical Optics, Vol. 22, No. 11, 115002, 01.11.2017.

Research output: Contribution to journalArticle

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