Nonhuman primate models of human viral infections

Jacob Estes, Scott Wong, Jason M. Brenchley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalNature Reviews Immunology
DOIs
StateAccepted/In press - Mar 19 2018

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Virus Diseases
Primates
Viral Vaccines
Viruses
Benchmarking
Antiviral Agents
Immune System
Pathology
Safety
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Nonhuman primate models of human viral infections. / Estes, Jacob; Wong, Scott; Brenchley, Jason M.

In: Nature Reviews Immunology, 19.03.2018, p. 1-15.

Research output: Contribution to journalArticle

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