Nonhuman primate models of human viral infections

Jacob D. Estes, Scott W. Wong, Jason M. Brenchley

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share many physiological parallels, such as highly similar immune systems, with them. Importantly, NHPs can be infected with many human or related simian viruses. In many cases, viruses replicate in the same cell types as in humans, and infections are often associated with the same pathologies. In addition, many reagents that are used to study the human immune response cross-react with NHP molecules. As such, NHPs are often used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy and to understand aspects of viral pathogenesis. With several emerging viral infections becoming epidemic, NHPs are proving to be a very beneficial benchmark for investigating human viral infections.

Original languageEnglish (US)
Pages (from-to)390-404
Number of pages15
JournalNature Reviews Immunology
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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