Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides

Melis Sardan, Adem Yildirim, Didem Mumcuoglu, Ayse B. Tekinay, Mustafa O. Guler

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The surface of mesoporous silica nanoparticles (MSNs) has been modified for enhancing their cellular uptake, cell targeting, bioimaging, and controlled drug release. For this purpose, covalent anchorage on the silica surface was predominantly exploited with a wide range of bioactive molecules. Here, we describe a facile self-assembly method to prepare a hybrid peptide silica system composed of octyl-modified mesoporous silica nanoparticles (MSNs) and peptide amphiphiles (PAs). The hydrophobic organosilane surface of mesoporous silica was coated with amphiphilic peptide molecules. The peptide functionalized particles exhibited good cyto-compatibility with vascular smooth muscle and vascular endothelial cells. The peptide coating also improved the cellular uptake of particles up to 6.3 fold, which is promising for the development of highly efficient MSN based theranostic agents.

Original languageEnglish (US)
Pages (from-to)2168-2174
Number of pages7
JournalJournal of Materials Chemistry B
Volume2
Issue number15
DOIs
StatePublished - Apr 21 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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