Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders

Sarah J. Byrnes, Thomas A. Angelovich, Kathleen Busman-Sahay, Catherine R. Cochrane, Michael Roche, Jacob D. Estes, Melissa J. Churchill

Research output: Contribution to journalReview articlepeer-review

Abstract

Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of disease is likely multifaceted, with contributions from viral reservoirs including the brain, chronic and systemic inflammation, and traditional risk factors including drug use. Elucidating the effects of each element on disease pathogenesis is near impossible in human clinical or ex vivo studies, facilitating the need for robust and accurate non-human primate models. In this review, we describe the major non-human primate models of neuroHIV infection, their use to study the acute, chronic, and virally suppressed infection of the brain, and novel therapies targeting brain reservoirs and inflammation.

Original languageEnglish (US)
Article number1997
JournalViruses
Volume14
Issue number9
DOIs
StatePublished - Sep 2022

Keywords

  • cognitive disorders
  • HIV
  • non-human primates
  • SIV

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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