Non-canonical Notch signaling: Emerging role and mechanism

Peter Andersen, Hideki Uosaki, Lincoln T. Shenje, Chulan Kwon

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalTrends in Cell Biology
Volume22
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

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Ligands
Catenins
Developmental Biology
Diptera
Cell Biology
Mammals

Keywords

  • Cancer
  • DAPT
  • Notch
  • Numb
  • Stem and progenitor cells
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Non-canonical Notch signaling : Emerging role and mechanism. / Andersen, Peter; Uosaki, Hideki; Shenje, Lincoln T.; Kwon, Chulan.

In: Trends in Cell Biology, Vol. 22, No. 5, 05.2012, p. 257-265.

Research output: Contribution to journalArticle

Andersen, P, Uosaki, H, Shenje, LT & Kwon, C 2012, 'Non-canonical Notch signaling: Emerging role and mechanism', Trends in Cell Biology, vol. 22, no. 5, pp. 257-265. https://doi.org/10.1016/j.tcb.2012.02.003
Andersen, Peter ; Uosaki, Hideki ; Shenje, Lincoln T. ; Kwon, Chulan. / Non-canonical Notch signaling : Emerging role and mechanism. In: Trends in Cell Biology. 2012 ; Vol. 22, No. 5. pp. 257-265.
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